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Gene Review

MTQ2  -  Mtq2p

Saccharomyces cerevisiae S288c

Synonyms: MTC6, N(5)-glutamine methyltransferase MTQ2, YDR140W, eRF1 MTase catalytic subunit MTQ2, eRF1 methyltransferase catalytic subunit MTQ2
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High impact information on MTQ2

  • In similar experiments, it was determined that Mtq2p methylates Sup45p [1].
  • A computational analysis revealed two yeast proteins, Mtq1p and Mtq2p, that have strong sequence similarity to PrmC [1].
  • The Sup45p methylation by Mtq2p was recently confirmed independently (Heurgue-Hamard, V., Champ, S., Mora, L., Merkulova-Rainon, T., Kisselev, L. L., and Buckingham, R. H. (2005) J. Biol. Chem. 280, 2439-2445) [1].
  • Most interestingly, the mtq2-Delta was significantly more resistant to the anti-microtubule drugs thiabendazole and benomyl, suggesting that Mtq2p may also methylate certain microtubule-related proteins [1].


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