Disease relevance of Mintezol

• Disruption of the CBF1 gene caused a decrease in the growth rate, an increase in the rate of chromosome loss/nondisjunction, and hypersensitivity to the antimitotic drug thiabendazole [1].
• Intrahepatic cholestasis and sicca complex after thiabendazole. Report of a case and review of the literature [2].
• The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed [2].
• Thiabendazole treatment of severe strongyloidiasis in a hemodialyzed patient [3].
• Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease [4].

Psychiatry related information on Mintezol

• Thiabendazole was found to be specifically effective against maximal electroshock seizures in albino rats [5].
• Thiabendazole significantly increased the reaction time to thermal stimulus [6].
• The effect of thiabendazole on pain threshold [6].
• Among the 31 patients treated with thiabendazole, 25 (78%) met the criteria for cure (the absence of parasite in faeces after examination of three samples collected on alternate days), and 5 (16%) experienced side effects (asthenia, epigastralgia and disorientation) [7].

High impact information on Mintezol

• Mutations in a cell-cycle gene NDA2 of Schizosaccharomyces pombe have pleiotropic effects on nuclear division, nuclear location, and thiabendazole sensitivity ( Toda et al., 1983) [8].
• Progressive bile duct injury after thiabendazole administration [9].
• Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract [2].
• We identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13-117 (cyclin B) and mal3-1 (EB-1) cells to thiabendazole, a microtubule poison [10].
• Alp4 function is required in G(1) phase and ts mutants become lethal before S-phase. alp4 and alp6 mutants are hypersensitive to the microtubule- destabilizing drug thiabendazole (TBZ) and show a lethal 'cut' phenotype in its presence [11].

Chemical compound and disease context of Mintezol

• The present study was designed to compare the efficacy of thiabendazole (TBZ) with that of levamisole in the treatment of murine lupus [4].
• The lack of toxicity of mebendazole makes it a desirable drug for Strongyloides infestation resistant to thiabendazole therapy [12].
• Albendazole and thiabendazole in murine strongyloidiasis [13].
• In vivo suppression of delayed hypersensitivity by thiabendazole and diethylcarbamazine [14].
• Murine strongyloidiasis: the effects of cyclosporin A and thiabendazole administered singly and in combination [15].

Biological context of Mintezol

• Furthermore, alp4mad2 double mutants show an exaggerated multiple septation phenotype in TBZ [11].
• To investigate the role of microtubules in regulating cell polarity in Schizosaccharomyces pombe, we have developed a system in which normally cylindrical fission yeast synchronously form branched cells at high frequency upon treatment with the microtubule-depolymerizing drug thiabendazole (TBZ) [16].
• Deletion of the Dicer (dcr1+) gene caused slow growth, sensitivity to thiabendazole, lagging chromosomes during anaphase, and abrogated silencing of centromeric repeats [17].
• Treatment of mating cells with the microtubule-destabilising drug thiabendazole (TBZ) showed that microtubule integrity was required for mating at two distinct stages: during projection tip formation and cell fusion [18].
• We show that only pst1-1 and not pst2Delta cells displayed anaphase defects and thiabendazole sensitivity. pst1-1 cells showed reduced centromeric silencing, increased histone acetylation in centromeric chromatin, and defective centromeric sister chromatid cohesion [19].

Anatomical context of Mintezol

• Morevoer, dim1-35 displays sensitivity to the microtubule destabilizing drug, thiabendazole (TBZ) [20].
• Perturbation of microtubules with the microtubule poison thiabendazole prevents the spindle pole body clustering in septation mutants, demonstrating that nuclear positioning requires a functional microtubule cytoskeleton [21].
• The 350 kDa antigen was part of the thiabendazole-induced cytoplasmic microtubule-organizing centers [22].
• The effect of thiabendazole in a mixed leukocyte culture [23].
• Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis [24].

Associations of Mintezol with other chemical compounds

• Disruption of the sts1+ gene does not lead to a sensitivity to thiabendazole or hydroxyurea [25].
• Vacuole fusion in fission yeast was inhibited by the microtubule drug thiabendazole (TBZ) but not by the actin inhibitor latrunculin B [26].
• OBJECTIVE: To determine whether combined chemotherapy with tinidazole, thiabendazole and cotrimoxazole is more effective than placebo in treatment of AIDS diarrhoea in Zambia. DESIGN: Single-blind prospective comparison in consecutive patients, randomized alternately to placebo or chemotherapy [27].
• All H. contortus tub-1 constructs, which encoded Phe at position 200, conferred susceptibility to thiabendazole in BZ-resistant C. elegans ben-1 mutants [28].
• The effects of the antiparasitic drugs levamisole, thiabendazole, praziquantel, and chloroquine on mitochondrial electron transport in muscle tissue from Ascaris suum [29].

Gene context of Mintezol

• We isolated a temperature-sensitive mutant allele of NPS1 , nps1-105, and found that the mutation increases the sensitivity to thiabendazole (TBZ) [30].
• A trf4 (ts) trf5 double mutant is hypersensitive to the anti-microtubule agent thiabendazole at a semi-permissive temperature, suggesting that TRF4/5 function is required at the time of mitosis [31].
• On the other hand, msl1 mutants but not nst1 mutants are sensitive to thiabendazole (a microtubule-destabilizing agent) and to osmotic stress [32].
• An rtt101 Delta strain was hypersensitive to thiabendazole, isopropyl ( N -3-chlorophenyl) carbamate and methyl methanesulphonate, but rub1 Delta strains were not [33].
• Most interestingly, the mtq2-Delta was significantly more resistant to the anti-microtubule drugs thiabendazole and benomyl, suggesting that Mtq2p may also methylate certain microtubule-related proteins [34].

Analytical, diagnostic and therapeutic context of Mintezol

• Biliary obstruction resulted from papillary stenosis, which resolved after treatment with thiabendazole [35].
• Disseminated strongyloidiasis complicating acute renal allograft rejection. Prolonged thiabendazole administration and successful retransplantation [36].
• Determination of thiabendazole residues in waters by solid-phase spectrofluorometry [37].
• Rectal administration of thiabendazole should be considered for patients unable to take the medication orally [38].
• When a new bronchoalveolar lavage sample and a new pulmonary biopsy specimen showed nematode larvae and adult worms, treatment with thiabendazole was started [39].

References