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Chemical Compound Review

Mintesol     2-(1,3-thiazol-4-yl)-1H- benzoimidazole

Synonyms: Arbotect, Bioguard, Bovizole, Mintezol, Omnizole, ...
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Disease relevance of Mintezol


Psychiatry related information on Mintezol


High impact information on Mintezol


Chemical compound and disease context of Mintezol


Biological context of Mintezol


Anatomical context of Mintezol


Associations of Mintezol with other chemical compounds


Gene context of Mintezol

  • We isolated a temperature-sensitive mutant allele of NPS1 , nps1-105, and found that the mutation increases the sensitivity to thiabendazole (TBZ) [30].
  • A trf4 (ts) trf5 double mutant is hypersensitive to the anti-microtubule agent thiabendazole at a semi-permissive temperature, suggesting that TRF4/5 function is required at the time of mitosis [31].
  • On the other hand, msl1 mutants but not nst1 mutants are sensitive to thiabendazole (a microtubule-destabilizing agent) and to osmotic stress [32].
  • An rtt101 Delta strain was hypersensitive to thiabendazole, isopropyl ( N -3-chlorophenyl) carbamate and methyl methanesulphonate, but rub1 Delta strains were not [33].
  • Most interestingly, the mtq2-Delta was significantly more resistant to the anti-microtubule drugs thiabendazole and benomyl, suggesting that Mtq2p may also methylate certain microtubule-related proteins [34].

Analytical, diagnostic and therapeutic context of Mintezol


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  2. Intrahepatic cholestasis and sicca complex after thiabendazole. Report of a case and review of the literature. Rex, D., Lumeng, L., Eble, J., Rex, L. Gastroenterology (1983) [Pubmed]
  3. Thiabendazole treatment of severe strongyloidiasis in a hemodialyzed patient. Schumaker, J.D., Band, J.D., Lensmeyer, G.L., Craig, W.A. Ann. Intern. Med. (1978) [Pubmed]
  4. Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease. Elgebaly, S.A., Forouhar, F., Dore-Duffy, P. Am. J. Pathol. (1984) [Pubmed]
  5. Anticonvulsant action of thiabendazole. Shashindran, C., Gandhi, I.S., Parmar, N.S. Eur. J. Pharmacol. (1977) [Pubmed]
  6. The effect of thiabendazole on pain threshold. Gomaa, A.A. Acta pharmacologica et toxicologica. (1985) [Pubmed]
  7. Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis. Igual-Adell, R., Oltra-Alcaraz, C., Soler-Company, E., Sánchez-Sánchez, P., Matogo-Oyana, J., Rodríguez-Calabuig, D. Expert opinion on pharmacotherapy. (2004) [Pubmed]
  8. Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombe. Toda, T., Adachi, Y., Hiraoka, Y., Yanagida, M. Cell (1984) [Pubmed]
  9. Progressive bile duct injury after thiabendazole administration. Manivel, J.C., Bloomer, J.R., Snover, D.C. Gastroenterology (1987) [Pubmed]
  10. The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. Sanchez-Perez, I., Renwick, S.J., Crawley, K., Karig, I., Buck, V., Meadows, J.C., Franco-Sanchez, A., Fleig, U., Toda, T., Millar, J.B. EMBO J. (2005) [Pubmed]
  11. The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint. Vardy, L., Toda, T. EMBO J. (2000) [Pubmed]
  12. Persistent Strongyloides stercoralis in a blind loop of the bowel. Successful treatment with mebendazole. Wilson, K.H., Kauffman, C.A. Arch. Intern. Med. (1983) [Pubmed]
  13. Albendazole and thiabendazole in murine strongyloidiasis. Mojon, M., Saura, C., Roojee, N., Tran Manh Sung, R. J. Antimicrob. Chemother. (1987) [Pubmed]
  14. In vivo suppression of delayed hypersensitivity by thiabendazole and diethylcarbamazine. Hewlett, E.L., Hamid, O.Y., Ruffier, J., Mahmoud, A.A. Immunopharmacology (1981) [Pubmed]
  15. Murine strongyloidiasis: the effects of cyclosporin A and thiabendazole administered singly and in combination. Armson, A., Cunningham, G.A., Grubb, W.B., Mendis, A.H. Int. J. Parasitol. (1995) [Pubmed]
  16. Regulation of cell polarity by microtubules in fission yeast. Sawin, K.E., Nurse, P. J. Cell Biol. (1998) [Pubmed]
  17. Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Provost, P., Silverstein, R.A., Dishart, D., Walfridsson, J., Djupedal, I., Kniola, B., Wright, A., Samuelsson, B., Radmark, O., Ekwall, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  18. Conjugation in S. pombe: identification of a microtubule-organising centre, a requirement for microtubules and a role for Mad2. Petersen, J., Heitz, M.J., Hagan, I.M. Curr. Biol. (1998) [Pubmed]
  19. A new role for the transcriptional corepressor SIN3; regulation of centromeres. Silverstein, R.A., Richardson, W., Levin, H., Allshire, R., Ekwall, K. Curr. Biol. (2003) [Pubmed]
  20. Fission yeast dim1(+) encodes a functionally conserved polypeptide essential for mitosis. Berry, L.D., Gould, K.L. J. Cell Biol. (1997) [Pubmed]
  21. Evidence for cell cycle-specific, spindle pole body-mediated, nuclear positioning in the fission yeast Schizosaccharomyces pombe. Hagan, I., Yanagida, M. J. Cell. Sci. (1997) [Pubmed]
  22. A novel structural component of the Dictyostelium centrosome. Kalt, A., Schliwa, M. J. Cell. Sci. (1996) [Pubmed]
  23. The effect of thiabendazole in a mixed leukocyte culture. Lovett, E.J., Lundy, J. Transplantation (1977) [Pubmed]
  24. Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis. Arroyo, J.C., Brown, A. J. Infect. Dis. (1987) [Pubmed]
  25. Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation. Shimanuki, M., Goebl, M., Yanagida, M., Toda, T. Mol. Biol. Cell (1992) [Pubmed]
  26. Myosin V-mediated vacuole distribution and fusion in fission yeast. Mulvihill, D.P., Pollard, P.J., Win, T.Z., Hyams, J.S. Curr. Biol. (2001) [Pubmed]
  27. Chemotherapy of African AIDS diarrhoea: a preliminary study. Kelly, P., Buve, A. AIDS (1993) [Pubmed]
  28. Beta-tubulin genes from the parasitic nematode Haemonchus contortus modulate drug resistance in Caenorhabditis elegans. Kwa, M.S., Veenstra, J.G., Van Dijk, M., Roos, M.H. J. Mol. Biol. (1995) [Pubmed]
  29. The effects of the antiparasitic drugs levamisole, thiabendazole, praziquantel, and chloroquine on mitochondrial electron transport in muscle tissue from Ascaris suum. Köhler, P., Bachmann, R. Mol. Pharmacol. (1978) [Pubmed]
  30. A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres. Tsuchiya, E., Hosotani, T., Miyakawa, T. Nucleic Acids Res. (1998) [Pubmed]
  31. A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation. Castaño, I.B., Heath-Pagliuso, S., Sadoff, B.U., Fitzhugh, D.J., Christman, M.F. Nucleic Acids Res. (1996) [Pubmed]
  32. Involvement of Nst1p/YNL091w and Msl1p, a U2B'' splicing factor, in Saccharomyces cerevisiae salt tolerance. Goossens, A., Forment, J., Serrano, R. Yeast (2002) [Pubmed]
  33. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Laplaza, J.M., Bostick, M., Scholes, D.T., Curcio, M.J., Callis, J. Biochem. J. (2004) [Pubmed]
  34. The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p. Polevoda, B., Span, L., Sherman, F. J. Biol. Chem. (2006) [Pubmed]
  35. Biliary obstruction resulting from Strongyloides stercoralis infection. Report of a case. Delarocque Astagneau, E., Hadengue, A., Degott, C., Vilgrain, V., Erlinger, S., Benhamou, J.P. Gut (1994) [Pubmed]
  36. Disseminated strongyloidiasis complicating acute renal allograft rejection. Prolonged thiabendazole administration and successful retransplantation. DeVault, G.A., Brown, S.T., Montoya, S.F., King, J.W., Rohr, M.S., McDonald, J.C. Transplantation (1982) [Pubmed]
  37. Determination of thiabendazole residues in waters by solid-phase spectrofluorometry. Capitán, F., Alonso, E., Avidad, R., Capitán-Vallvey, L.F., Vilchez, J.L. Anal. Chem. (1993) [Pubmed]
  38. Treatment of Strongyloides stercoralis hyperinfection syndrome with thiabendazole administered per rectum. Boken, D.J., Leoni, P.A., Preheim, L.C. Clin. Infect. Dis. (1993) [Pubmed]
  39. Fatal human pulmonary infection caused by an Angiostrongylus-like nematode. Pirisi, M., Gutiérrez, Y., Minini, C., Dolcet, F., Beltrami, C.A., Pizzolito, S., Pitzus, E., Bartoli, E. Clin. Infect. Dis. (1995) [Pubmed]
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