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Gene Review:

SRB7 - Srb7p

Saccharomyces cerevisiae S288c

Synonyms: D9740.17, MED21, Mediator complex subunit 21, Mediator of RNA polymerase II transcription subunit 21, RNAPII complex component SRB7, ...

Mennella, T.A. et al., Hallberg, M. et al., Gromöller, A. et al.

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High impact information on SRB7

Srb7p is a physical and physiological target of Tup1p [1].
Furthermore, we find that Srb7p also binds Med6p and that this interaction is necessary for full transcriptional activation by different activators [1].
Med21 (Srb7) is a small essential subunit of the middle domain of the Mediator, which is conserved in all eukaryotes [2].

Biological context of SRB7

The mediator factor Srb7 has been shown to interact with Tup1 and to play a role in repression at several regulons, but we found that significant levels of repression remained in srb7 mutants even when the chromatin-dependent repression mechanism was eliminated [3].

Physical interactions of SRB7

In the yeast Saccharomyces cerevisiae, Med21 is known to interact both with the Mediator subunit Med6 and the global co-repressor Tup1 [2].

References

Srb7p is a physical and physiological target of Tup1p. Gromöller, A., Lehming, N. EMBO J. (2000) [Pubmed]
Functional and physical interactions within the middle domain of the yeast mediator. Hallberg, M., Hu, G.Z., Tronnersjö, S., Shaikhibrahim, Z., Balciunas, D., Björklund, S., Ronne, H. Mol. Genet. Genomics (2006) [Pubmed]
Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein. Mennella, T.A., Klinkenberg, L.G., Zitomer, R.S. Eukaryotic Cell (2003) [Pubmed]

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AGOS_AAL049C	Ashbya gossypii ATCC 10895
KLLA0C14806g	Kluyveromyces lactis NRRL Y-1140

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