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Gene Review

RPS17B  -  ribosomal 40S subunit protein S17B

Saccharomyces cerevisiae S288c

Synonyms: 40S ribosomal protein S17-B, RP51B, RPL51B, YDR447C
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High impact information on RPS17B

  • We altered the RP51 gene dose by creating deletions of the RP51A or RP51B genes or both [1].
  • Rap1p DNA-binding sites in ribosomal protein gene promoters are mainly UASrpg-like; their replacement by telomeric sequences in one of these promoters (RPS17B) decreased transcription by two-thirds [2].

Biological context of RPS17B

  • The cloned genes, in combination with the one-step gene disruption techniques of Rothstein (R. J. Rothstein, Methods Enzymol. 101:202-211, 1983), were used to generate haploid strains containing mutations in the RP51A or RP51B genes or in both [3].

Other interactions of RPS17B

  • The results of Northern blot and primer extension experiments indicate that strains with a wild-type copy of the RP51B gene and a mutant (or deleted) RP51A gene grow slowly because of an insufficient amount of RP51 mRNA [3].


  1. Effect of RP51 gene dosage alterations on ribosome synthesis in Saccharomyces cerevisiae. Abovich, N., Gritz, L., Tung, L., Rosbash, M. Mol. Cell. Biol. (1985) [Pubmed]
  2. Alternative mechanisms of transcriptional activation by Rap1p. Idrissi, F.Z., Garcia-Reyero, N., Fernandez-Larrea, J.B., Piña, B. J. Biol. Chem. (2001) [Pubmed]
  3. Two genes for ribosomal protein 51 of Saccharomyces cerevisiae complement and contribute to the ribosomes. Abovich, N., Rosbash, M. Mol. Cell. Biol. (1984) [Pubmed]
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