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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLD5  -  Sld5p

Saccharomyces cerevisiae S288c

Synonyms: DNA replication complex GINS protein SLD5, YDR489W
 
 
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High impact information on SLD5

  • Since the conditional mutations of Sld5 and Psf1 confer defect of DNA replication under nonpermissive conditions, GINS is suggested to function for chromosomal DNA replication [1].
  • The chromatin binding of the complex and that of Cdc45 are mutually dependent and both bindings require Xenopus Cut5, the yeast homolog of which interacts with Sld5 [2].

References

  1. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Takayama, Y., Kamimura, Y., Okawa, M., Muramatsu, S., Sugino, A., Araki, H. Genes Dev. (2003) [Pubmed]
  2. A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Kubota, Y., Takase, Y., Komori, Y., Hashimoto, Y., Arata, T., Kamimura, Y., Araki, H., Takisawa, H. Genes Dev. (2003) [Pubmed]
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