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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PTH2  -  Pth2p

Saccharomyces cerevisiae S288c

Synonyms: PTH 2, Peptidyl-tRNA hydrolase 2, YBL0510, YBL0514, YBL057C
 
 
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High impact information on PTH2

  • Ubiquitin-dependent degradation was accelerated in the pth2Delta mutant and was retarded by overexpression of Pth2 [1].
  • Furthermore, Pth2 function involving UBL-UBA proteins was independent of its peptidyl-tRNA hydrolase activity [1].
  • The phylogeny of pth2 homologs suggests that the gene has been vertically inherited throughout the archaeal and eukaryal domains [2].
  • Analysis of known genomes revealed the presence of highly conserved orthologs of the archaeal pth2 gene in all archaea and eukaryotes but not in bacteria [2].
 

Analytical, diagnostic and therapeutic context of PTH2

References

  1. Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. Ishii, T., Funakoshi, M., Kobayashi, H. EMBO J. (2006) [Pubmed]
  2. Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Rosas-Sandoval, G., Ambrogelly, A., Rinehart, J., Wei, D., Cruz-Vera, L.R., Graham, D.E., Stetter, K.O., Guarneros, G., Söll, D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay. Zhang, C.L., Tada, M., Kobayashi, H., Nozaki, M., Moriuchi, T., Abe, H. Oncogene (2000) [Pubmed]
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