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Gene Review

PTH1  -  Pth1p

Saccharomyces cerevisiae S288c

Synonyms: PTH, Peptidyl-tRNA hydrolase, YHR189W
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Disease relevance of PTH1


High impact information on PTH1


  1. Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable. Menez, J., Buckingham, R.H., de Zamaroczy, M., Campelli, C.K. Mol. Microbiol. (2002) [Pubmed]
  2. Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene of Escherichia coli. De La Vega, F.M., Galindo, J.M., Old, I.G., Guarneros, G. Gene (1996) [Pubmed]
  3. Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. Ishii, T., Funakoshi, M., Kobayashi, H. EMBO J. (2006) [Pubmed]
  4. Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Rosas-Sandoval, G., Ambrogelly, A., Rinehart, J., Wei, D., Cruz-Vera, L.R., Graham, D.E., Stetter, K.O., Guarneros, G., Söll, D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. The site of hydrolysis by rabbit reticulocyte peptidyl-tRNA hydrolase is the 3'-AMP terminus of susceptible tRNA substrates. Gross, M., Crow, P., White, J. J. Biol. Chem. (1992) [Pubmed]
  6. New protein functions in yeast chromosome VIII. Ouzounis, C., Bork, P., Casari, G., Sander, C. Protein Sci. (1995) [Pubmed]
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