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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

STU1  -  Stu1p

Saccharomyces cerevisiae S288c

Synonyms: Protein STU1, Suppressor of tubulin 1, YBL034C, YBL0416
 
 
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High impact information on STU1

  • STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle [1].
  • The nucleotide sequence of the STU1 gene predicts a protein product of 174 kD with no significant similarity to known proteins [1].
  • Taken together, these findings suggest that Stu1p binds to interpolar microtubules of the mitotic spindle and plays an essential role in their ability to provide an outward force on the spindle poles [2].
  • Stu1p was observed to be a component of the mitotic spindle localizing to the midregion of anaphase spindles [2].
  • The levels of Stu1p are even lower in ubp3Delta stu1-5 cells, suggesting that Ubp3p plays a role in promoting protein stability [3].

References

  1. STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle. Pasqualone, D., Huffaker, T.C. J. Cell Biol. (1994) [Pubmed]
  2. Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle. Yin, H., You, L., Pasqualone, D., Kopski, K.M., Huffaker, T.C. Mol. Biol. Cell (2002) [Pubmed]
  3. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Brew, C.T., Huffaker, T.C. Genetics (2002) [Pubmed]
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