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Gene Review

FMT1  -  Fmt1p

Saccharomyces cerevisiae S288c

Synonyms: Methionyl-tRNA formyltransferase, mitochondrial, MtFMT, YBL013W, YBL0311, YBL0313
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High impact information on FMT1

  • The ability of bovine mIF2 to support mitochondrial translation in the yeast fmt1 mutant suggests that this phenomenon may extend to mammalian mitochondria as well [1].
  • We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C(1)-tetrahydrofolate (C(1)-THF) synthase (MIS1), necessary for synthesis of 10-formyl-THF, and the methionyl-tRNA formyltransferase (open reading frame YBL013W; designated FMT1) [2].

Biological context of FMT1

  • The only growth phenotype observed was a longer lag time during growth on nonfermentable carbon sources in minimal media for the mis1 deletion strain but not for the fmt1 deletion strain [2].


  1. Mammalian mitochondrial initiation factor 2 supports yeast mitochondrial translation without formylated initiator tRNA. Tibbetts, A.S., Oesterlin, L., Chan, S.Y., Kramer, G., Hardesty, B., Appling, D.R. J. Biol. Chem. (2003) [Pubmed]
  2. Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. Li, Y., Holmes, W.B., Appling, D.R., RajBhandary, U.L. J. Bacteriol. (2000) [Pubmed]
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