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Gene Review: 

OST5  -  Ost5p

Saccharomyces cerevisiae S288c

Synonyms: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5, Oligosaccharyl transferase 9.5 kDa subunit, Oligosaccharyl transferase subunit OST5, Oligosaccharyl transferase subunit zeta, YGL226BC, ...
 
 
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High impact information on OST5

  • Suppression of an ost1 mutation by overexpression of OST5 indicates that this small membrane protein directly interacts with other OTase components, most likely with Ost1p [1].
  • In the case of Ost5p and Ost6p, both their N and C termini are present in the cytosol [2].

References

  1. A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro. Reiss, G., te Heesen, S., Gilmore, R., Zufferey, R., Aebi, M. EMBO J. (1997) [Pubmed]
  2. Studies of yeast oligosaccharyl transferase subunits using the split-ubiquitin system: topological features and in vivo interactions. Yan, A., Wu, E., Lennarz, W.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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