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TIM21  -  Tim21p

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial import inner membrane translocase subunit TIM21, YGR033C
 
 
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High impact information on TIM21

  • Tim21 is specific for a TIM23 form that cooperates with TOM and promotes inner membrane insertion [1].
  • Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17 [1].
  • Protein translocation into the matrix requires a switch to a Tim21-free, PAM bound presequence translocase [1].
 

Physical interactions of TIM21

  • The purified C-terminal domain of Tim21 appears not to bind to any of the TIM23 components but rather specifically interacts with the TOM complex [2].
  • We also identified a core sequence of Tom22 that binds to Tim21 [3].

References

  1. Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., Rehling, P. Cell (2005) [Pubmed]
  2. Role of Tim21 in mitochondrial translocation contact sites. Mokranjac, D., Popov-Celeketić, D., Hell, K., Neupert, W. J. Biol. Chem. (2005) [Pubmed]
  3. The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. Albrecht, R., Rehling, P., Chacinska, A., Brix, J., Cadamuro, S.A., Volkmer, R., Guiard, B., Pfanner, N., Zeth, K. EMBO Rep. (2006) [Pubmed]
 
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