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Gene Review

SRB5  -  Srb5p

Saccharomyces cerevisiae S288c

Synonyms: MED18, Mediator complex subunit 18, Mediator of RNA polymerase II transcription subunit 18, Suppressor of RNA polymerase B 5, YGR104C
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High impact information on SRB5

  • In vitro transcription and template commitment assays confirm that SRB2 and SRB5 are components of a functional preinitiation complex and are required for efficient transcription initiation [1].
  • Epistasis analysis with expression-profile phenotypes shows that MED2 and MED18 are downstream of CDK8 [2].
  • Surprisingly, fusions with neither Srb5 nor Med9 circumvented TFIIE requirement for the CUP1 activation [3].

Analytical, diagnostic and therapeutic context of SRB5

  • Immunoprecipitation experiments with anti-SRB5 antibodies demonstrate that the acidic activating domain of VP16 specifically binds to the holoenzyme [4].


  1. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Thompson, C.M., Koleske, A.J., Chao, D.M., Young, R.A. Cell (1993) [Pubmed]
  2. Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. van de Peppel, J., Kettelarij, N., van Bakel, H., Kockelkorn, T.T., van Leenen, D., Holstege, F.C. Mol. Cell (2005) [Pubmed]
  3. Artificial recruitment of certain Mediator components affects requirement of basal transcription factor IIE. Sakurai, H., Fukasawa, T. Genes Cells (2003) [Pubmed]
  4. Association of an activator with an RNA polymerase II holoenzyme. Hengartner, C.J., Thompson, C.M., Zhang, J., Chao, D.M., Liao, S.M., Koleske, A.J., Okamura, S., Young, R.A. Genes Dev. (1995) [Pubmed]
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