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Gene Review:

MED2 - Med2p

Saccharomyces cerevisiae S288c

Synonyms: D2930, Mediator complex subunit 2, Mediator of RNA polymerase II transcription subunit 2, YDL005C

Hallberg, M. et al., Smith, K.N. et al., van de Peppel, J. et al.

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High impact information on MED2

Epistasis analysis with expression-profile phenotypes shows that MED2 and MED18 are downstream of CDK8 [1].
Here, we show that the cyclin-dependent kinase Srb10 interacts with, and phosphorylates, the Med2 subunit of Mediator both in vivo and in vitro [2].
A point mutation of the single phosphorylation site in Med2 results in a strongly reduced expression of the REP1, REP2, FLP1, and RAF1 genes, which are all located on the endogenous 2-microm plasmid [2].
Disruption and functional analysis of seven ORFs on chromosome IV: YDL057w, YDL012c, YDL010w, YDL009c, YDL008w (APC11), YDL005c (MED2) and YDL003w (MCD1) [3].
The remaining ORF, YDL005c (also termed MED2), encodes a component of the transcriptional activator complex known as Mediator [3].

Biological context of MED2

Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid [2].

References

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. van de Peppel, J., Kettelarij, N., van Bakel, H., Kockelkorn, T.T., van Leenen, D., Holstege, F.C. Mol. Cell (2005) [Pubmed]
Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid. Hallberg, M., Polozkov, G.V., Hu, G.Z., Beve, J., Gustafsson, C.M., Ronne, H., Björklund, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Disruption and functional analysis of seven ORFs on chromosome IV: YDL057w, YDL012c, YDL010w, YDL009c, YDL008w (APC11), YDL005c (MED2) and YDL003w (MCD1). Smith, K.N., Iwanejko, L., Loeillet, S., Fabre, F., Nicolas, A. Yeast (1999) [Pubmed]

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