Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CSE2 - Cse2p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome segregation protein 2, MED9, Mediator complex subunit 9, Mediator of RNA polymerase II transcription subunit 9, N2046, ...

Kang, J.S. et al., Xiao, Z.X. et al., Tomomori-Sato, C. et al., Han, S.J. et al., Gustafsson, C.M. et al.

Gustafsson, Myers, Beve, Spåhr, Lui, Erdjument-Bromage, Tempst, Kornberg,

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High impact information on CSE2

In addition, we present evidence that Med25 shares structural and functional properties with Saccharomyces cerevisiae Mediator subunit Cse2 and may be a mammalian Cse2 ortholog [1].
Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes [2].
Proteins in the Med9 submodule interact physically and genetically with Srb10/11, suggesting that the Med9 submodule mediates the repression of pol II [3].
The Rgr1 subcomplex is composed of the Gal11 module, which binds activators, and the Med9/10 module [3].
The Med9/10 module is required for both transcriptional activation and repression, and these activities appear to be carried out by two submodules [3].

Biological context of CSE2

These data suggest a functional interaction between the CSE2 protein and the yeast centromere [4].
Here, we report that disruption of CSE2 results in a significant increase in chromosome missegregation, slower growth and defective meiosis [4].
The combination of the CSE2 disruption and a mutant centromere results in a synergistic effect on both cell growth and cell viability [4].

Other interactions of CSE2

These are the products of the NUT2, CSE2, and MED11 genes [5].

References

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. Tomomori-Sato, C., Sato, S., Parmely, T.J., Banks, C.A., Sorokina, I., Florens, L., Zybailov, B., Washburn, M.P., Brower, C.S., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2004) [Pubmed]
Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes. Han, S.J., Lee, J.S., Kang, J.S., Kim, Y.J. J. Biol. Chem. (2001) [Pubmed]
The structural and functional organization of the yeast mediator complex. Kang, J.S., Kim, S.H., Hwang, M.S., Han, S.J., Lee, Y.C., Kim, Y.J. J. Biol. Chem. (2001) [Pubmed]
Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. Xiao, Z.X., Fitzgerald-Hayes, M. J. Mol. Biol. (1995) [Pubmed]
Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson, C.M., Myers, L.C., Beve, J., Spåhr, H., Lui, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D. J. Biol. Chem. (1998) [Pubmed]

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