The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

CSE2  -  Cse2p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome segregation protein 2, MED9, Mediator complex subunit 9, Mediator of RNA polymerase II transcription subunit 9, N2046, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CSE2

  • In addition, we present evidence that Med25 shares structural and functional properties with Saccharomyces cerevisiae Mediator subunit Cse2 and may be a mammalian Cse2 ortholog [1].
  • Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes [2].
  • Proteins in the Med9 submodule interact physically and genetically with Srb10/11, suggesting that the Med9 submodule mediates the repression of pol II [3].
  • The Rgr1 subcomplex is composed of the Gal11 module, which binds activators, and the Med9/10 module [3].
  • The Med9/10 module is required for both transcriptional activation and repression, and these activities appear to be carried out by two submodules [3].

Biological context of CSE2


Other interactions of CSE2


  1. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. Tomomori-Sato, C., Sato, S., Parmely, T.J., Banks, C.A., Sorokina, I., Florens, L., Zybailov, B., Washburn, M.P., Brower, C.S., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2004) [Pubmed]
  2. Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes. Han, S.J., Lee, J.S., Kang, J.S., Kim, Y.J. J. Biol. Chem. (2001) [Pubmed]
  3. The structural and functional organization of the yeast mediator complex. Kang, J.S., Kim, S.H., Hwang, M.S., Han, S.J., Lee, Y.C., Kim, Y.J. J. Biol. Chem. (2001) [Pubmed]
  4. Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. Xiao, Z.X., Fitzgerald-Hayes, M. J. Mol. Biol. (1995) [Pubmed]
  5. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson, C.M., Myers, L.C., Beve, J., Spåhr, H., Lui, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D. J. Biol. Chem. (1998) [Pubmed]
WikiGenes - Universities