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Gene Review:

TIF4631 - Tif4631p

Saccharomyces cerevisiae S288c

Synonyms: Eukaryotic initiation factor 4F subunit p150, YGR162W, eIF-4F p150, eIF4F p150, eIF4G1, ...

Goyer, C. et al., Tarun, S.Z. et al., Barnes, C.A. et al., Vergé, V. et al.

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High impact information on TIF4631

Here we report that the two yeast eIF4G homologs, Tif4631p and Tif4632p, share a conserved Pab1p-binding site [1].
This region on Tif4631p becomes essential for cell growth when the eIF4E binding site on Tif4631p is mutated [1].
Localization of a promoter in the putative internal ribosome entry site of the Saccharomyces cerevisiae TIF4631 gene [2].
Efficient Ssa1-LacZ polypeptide synthesis was also seen during eIF-4F limitation produced by disruption of the TIF4631 gene, encoding the large eIF-4F subunit [3].

Biological context of TIF4631

Both proteins contain sequences resembling the RNA recognition motif and auxiliary domains that are characteristic of a large family of RNA-binding proteins. tif4631-disrupted strains exhibited a slow-growth, cold-sensitive phenotype, while disruption of TIF4632 failed to show any phenotype under the conditions assayed [4].

References

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. Tarun, S.Z., Wells, S.E., Deardorff, J.A., Sachs, A.B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Localization of a promoter in the putative internal ribosome entry site of the Saccharomyces cerevisiae TIF4631 gene. Vergé, V., Vonlanthen, M., Masson, J.M., Trachsel, H., Altmann, M. RNA (2004) [Pubmed]
Efficient translation of an SSA1-derived heat-shock mRNA in yeast cells limited for cap-binding protein and eIF-4F. Barnes, C.A., MacKenzie, M.M., Johnston, G.C., Singer, R.A. Mol. Gen. Genet. (1995) [Pubmed]
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Goyer, C., Altmann, M., Lee, H.S., Blanc, A., Deshmukh, M., Woolford, J.L., Trachsel, H., Sonenberg, N. Mol. Cell. Biol. (1993) [Pubmed]

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