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Gene Review

TIF4632  -  Tif4632p

Saccharomyces cerevisiae S288c

Synonyms: Eukaryotic initiation factor 4F subunit p130, YGL049C, eIF-4F p130, eIF4F p130, eIF4G2, ...
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High impact information on TIF4632


Biological context of TIF4632

  • Both proteins contain sequences resembling the RNA recognition motif and auxiliary domains that are characteristic of a large family of RNA-binding proteins. tif4631-disrupted strains exhibited a slow-growth, cold-sensitive phenotype, while disruption of TIF4632 failed to show any phenotype under the conditions assayed [4].


  1. Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. Tarun, S.Z., Wells, S.E., Deardorff, J.A., Sachs, A.B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Binding of eukaryotic translation initiation factor 4E (eIF4E) to eIF4G represses translation of uncapped mRNA. Tarun, S.Z., Sachs, A.B. Mol. Cell. Biol. (1997) [Pubmed]
  3. The Saccharomyces cerevisiae RNA-binding protein Rbp29 functions in cytoplasmic mRNA metabolism. Winstall, E., Sadowski, M., Kuhn, U., Wahle, E., Sachs, A.B. J. Biol. Chem. (2000) [Pubmed]
  4. TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Goyer, C., Altmann, M., Lee, H.S., Blanc, A., Deshmukh, M., Woolford, J.L., Trachsel, H., Sonenberg, N. Mol. Cell. Biol. (1993) [Pubmed]
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