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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ELP2  -  Elongator subunit ELP2

Saccharomyces cerevisiae S288c

Synonyms: Elongator complex protein 2, G7725, Gamma-toxin target 2, KTI3, TOT2, ...
 
 
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High impact information on ELP2

  • ELP2 encodes a protein with eight WD40 repeats, and cells lacking the gene display typical elp phenotypes, such as temperature and salt sensitivity [1].
  • Consistently, the Tot1-3/Elp1-3 proteins expressed from the mTn3-tagged genes were all predicted to be C-terminally truncated, lacking approximately 80% of Tot1p, five WD40 Tot2p repeats and two HAT motifs of Tot3p [2].
 

Other interactions of ELP2

  • Despite being dispensable for Tot4-Tot2 interaction, the extreme C-terminus of Tot1p may play a role in TOT/Elongator function, as its truncation confers zymocin resistance [2].

References

  1. The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein. Fellows, J., Erdjument-Bromage, H., Tempst, P., Svejstrup, J.Q. J. Biol. Chem. (2000) [Pubmed]
  2. Protein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity. Fichtner, L., Frohloff, F., Jablonowski, D., Stark, M.J., Schaffrath, R. Mol. Microbiol. (2002) [Pubmed]
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