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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ELP2  -  elongator acetyltransferase complex subunit 2

Homo sapiens

Synonyms: Elongator complex protein 2, FLJ10879, SHINC-2, STAT3-interacting protein 1, STATIP1, ...
 
 
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Disease relevance of ELP2

 

High impact information on ELP2

  • A Stat3-interacting protein (StIP1) regulates cytokine signal transduction [2].
  • These studies indicate that StIP1 regulates the ligand-dependent activation of Stat3, potentially by serving as a scaffold protein that promotes the interaction between Janus kinases and their Stat3 substrate [2].
  • In the human testis, two rare transcripts were characterized, hELP1 and hELP2, the products of independent duplicated genes [3].
 

Analytical, diagnostic and therapeutic context of ELP2

  • The ability of StIP1 to associate with several additional members of the signal transducer and activator of transcription family suggests that StIP1 may serve a broader role in cytokine-signaling events [2].

References

  1. Silent myocardial ischemia in Kawasaki disease: evaluation of percutaneous transluminal coronary angioplasty by dobutamine stress testing. Ogawa, S., Fukazawa, R., Ohkubo, T., Zhang, J., Takechi, N., Kuramochi, Y., Hino, Y., Jimbo, O., Katsube, Y., Kamisago, M., Genma, Y., Yamamoto, M. Circulation (1997) [Pubmed]
  2. A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Collum, R.G., Brutsaert, S., Lee, G., Schindler, C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Progressive inactivation of the haploid expressed gene for the sperm-specific endozepine-like peptide (ELP) through primate evolution. Ivell, R., Pusch, W., Balvers, M., Valentin, M., Walther, N., Weinbauer, G. Gene (2000) [Pubmed]
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