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Gene Review

SLI1  -  Sli1p

Saccharomyces cerevisiae S288c

Synonyms: N-acetyltransferase SLI1, Sphingosine-like immunosuppressant resistant protein 1, YGR212W
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High impact information on SLI1

  • A PTB domain-inactivating point mutation (G306E), corresponding to a loss-of-function mutation in the Caenorhabditis elegans Cbl homologue SLI-1, severely compromised Cbl-N/Syk binding in vitro and Cbl/Syk association in transfected COS-7 cells [1].
  • Although a sli1-null strain grew normally, the IC50 of ISP-1 for the growth of this strain was markedly decreased compared with that for the parental strain, indicating that Sli1p is a major contributor to ISP-1 resistance in yeast [2].
  • On a sli1-null background, the increase in resistance to ISP-1 induced by YPK1 gene transfection was almost abolished [2].


  1. Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323. Lupher, M.L., Rao, N., Lill, N.L., Andoniou, C.E., Miyake, S., Clark, E.A., Druker, B., Band, H. J. Biol. Chem. (1998) [Pubmed]
  2. SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast. Momoi, M., Tanoue, D., Sun, Y., Takematsu, H., Suzuki, Y., Suzuki, M., Suzuki, A., Fujita, T., Kozutsumi, Y. Biochem. J. (2004) [Pubmed]
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