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Gene Review

ASG7  -  Asg7p

Saccharomyces cerevisiae S288c

Synonyms: A-specific gene 7 protein, J0514, Protein ASG7, YJL170C
 
 
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High impact information on ASG7

  • Asg7p-Ste3p inhibition of pheromone signaling: regulation of the zygotic transition to vegetative growth [1].
  • Localization and signaling of G(beta) subunit Ste4p are controlled by a-factor receptor and the a-specific protein Asg7p [2].
  • Together these results suggest a mechanism in which, following the zygotic fusion event, Ste3p and Asg7p gain access to one another and together act to repress the pheromone response, promoting the transition of the new diploid cell to vegetative growth [1].
  • SCYJL170C is repressed by alpha2-Mcm1 in vivo and therefore using this method we have identified a new a-specific gene, which we call ASG7 [3].
  • We identified two genes, SST2 and ASG7 [4].
 

Other interactions of ASG7

  • Asg7 is an a -cell specific protein that acts in concert with the alpha-cell specific a -factor receptor, Ste3, to inhibit signaling by Gbetagamma [4].

References

  1. Asg7p-Ste3p inhibition of pheromone signaling: regulation of the zygotic transition to vegetative growth. Roth, A.F., Nelson, B., Boone, C., Davis, N.G. Mol. Cell. Biol. (2000) [Pubmed]
  2. Localization and signaling of G(beta) subunit Ste4p are controlled by a-factor receptor and the a-specific protein Asg7p. Kim, J., Bortz, E., Zhong, H., Leeuw, T., Leberer, E., Vershon, A.K., Hirsch, J.P. Mol. Cell. Biol. (2000) [Pubmed]
  3. Identification of target sites of the alpha2-Mcm1 repressor complex in the yeast genome. Zhong, H., McCord, R., Vershon, A.K. Genome Res. (1999) [Pubmed]
  4. Autocrine activation of the pheromone response pathway in matalpha2- cells is attenuated by SST2- and ASG7-dependent mechanisms. Rivers, D.M., Sprague, G.F. Mol. Genet. Genomics (2003) [Pubmed]
 
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