High impact information on JEM1

• In contrast, deletion of JEM1 and SCJ1 had little effect on the ERAD of a membrane protein [1].
• These results suggest that one role of the BiP, Jem1p, and Scj1p chaperones is to maintain lumenal ERAD substrates in a retrotranslocation-competent state [1].
• Analysis of double mutants suggested that Kar5p acts before Kar8/Jem1p [2].
• KAR8 is allelic to JEMI, encoding an endoplasmic reticulum resident DnaJ protein required for nuclear fusion [2].
• Two genes, KAR7 and KAR8, were previously identified by mutations that cause defects in nuclear membrane fusion [2].

Biological context of JEM1

• Translation of Jem1p starts from the second ATG codon of the previously assumed JEM1 open reading frame, leading to the synthesis of a precursor protein of 645 amino acids long [3].

Other interactions of JEM1

• We also present evidence indicating that the G1 cyclin-dependent control of Glt1p may involve Jem1p, a DnaJ-type chaperone [4].

References