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Gene Review

DGCR6L  -  DiGeorge syndrome critical region gene 6-like

Homo sapiens

Synonyms: DiGeorge syndrome critical region 6-like protein, FLJ10666, Protein DGCR6L
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High impact information on DGCR6L

  • We mapped the DGCR6 gene to chromosome 22q11 within a low copy repeat, termed sc11.1a, and identified a second copy of the gene, DGCR6L, within the duplicate locus, termed sc11.1b [1].
  • As the DGCR6 protein(s) influence gene expression in trans, we analysed the influence of DGCR6/DGCR6L on the Epstein-Barr virus-encoded oncoproteins EBNA2 and EBNA3c in the activation of the viral LMP1 promoter, as well as LMP1-mediated activation of NFkB, but found no effect in either setting [2].


  1. Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus. Edelmann, L., Stankiewicz, P., Spiteri, E., Pandita, R.K., Shaffer, L., Lupski, J.R., Morrow, B.E., Lupski, J. Genome Res. (2001) [Pubmed]
  2. Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes. Pfuhl, T., Dürr, M., Spurk, A., Schwalbert, B., Nord, R., Mysliwietz, J., Kremmer, E., Grässer, F.A. Hum. Genet. (2005) [Pubmed]
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