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Gene Review:

CAF4 - Caf4p

Saccharomyces cerevisiae S288c

Synonyms: CCR4-associated factor 4, YKR036C

Griffin, E.E. et al., Liu, H.Y. et al., Schauss, A.C. et al.

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High impact information on CAF4

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria [1].
We identify the WD40 repeat protein Caf4p as a Fis1p-associated protein that localizes to mitochondria in a Fis1p-dependent manner [1].
CAF4 also displayed physical interactions with multiple CCR4-NOT components and with DBF2, a likely component of the 1.9-MDa complex [2].

Analytical, diagnostic and therapeutic context of CAF4

Using quantitative confocal microscopy, we show that Caf4p is important for the recruitment of Dnm1p to the mitochondria [3].

References

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. Griffin, E.E., Graumann, J., Chan, D.C. J. Cell Biol. (2005) [Pubmed]
Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. Liu, H.Y., Chiang, Y.C., Pan, J., Chen, J., Salvadore, C., Audino, D.C., Badarinarayana, V., Palaniswamy, V., Anderson, B., Denis, C.L. J. Biol. Chem. (2001) [Pubmed]
Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface. Schauss, A.C., Bewersdorf, J., Jakobs, S. J. Cell. Sci. (2006) [Pubmed]

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