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Gene Review

MTD1  -  methylenetetrahydrofolate dehydrogenase...

Saccharomyces cerevisiae S288c

Synonyms: YKR080W, YKR400
 
 
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High impact information on MTD1

  • Disruption of the MTD1 gene in this strain resulted in undetectable CHO-THF, indicating that the NAD-dependent CH2-THF dehydrogenase was responsible for CHO-THF production in the ade3 deletion strain [1].
  • Saccharomyces cerevisiae possesses two cytosolic 5,10-methylenetetrahydrofolate (CH2-THF) dehydrogenases that differ in their redox cofactor specificity: an NAD-dependent dehydrogenase encoded by the MTD1 gene and an NADP-dependent activity as part of the trifunctional C1-THF synthase encoded by the ADE3 gene [1].
  • Northern analysis reveals that regulation of SHM2 and MTD1 expression by adenine takes place at the transcriptional level [2].
  • This segment contains nine complete open reading frames (ORFs), YKR401 to YKR409, and part of another ORF, YKR400, covering altogether 87.2% of the entire sequence [3].

References

  1. Metabolic role of cytoplasmic isozymes of 5,10-methylenetetrahydrofolate dehydrogenase in Saccharomyces cerevisiae. West, M.G., Horne, D.W., Appling, D.R. Biochemistry (1996) [Pubmed]
  2. Synthesis of glutamine, glycine and 10-formyl tetrahydrofolate is coregulated with purine biosynthesis in Saccharomyces cerevisiae. Denis, V., Daignan-Fornier, B. Mol. Gen. Genet. (1998) [Pubmed]
  3. The complete sequence of an 18,002 bp segment of Saccharomyces cerevisiae chromosome XI contains the HBS1, MRP-L20 and PRP16 genes, and six new open reading frames. García-Cantalejo, J., Baladrón, V., Esteban, P.F., Santos, M.A., Bou, G., Remacha, M.A., Revuelta, J.L., Ballesta, J.P., Jiménez, A., del Rey, F. Yeast (1994) [Pubmed]
 
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