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Gene Review:

DOCK7 - dedicator of cytokinesis 7

Homo sapiens

Synonyms: Dedicator of cytokinesis protein 7, EIEE23, KIAA1771, ZIR2

Watabe-Uchida, M. et al., Nellist, M. et al.

Nellist, Burgers, van den Ouweland, Halley, Luider,

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High impact information on DOCK7

The Rac Activator DOCK7 Regulates Neuronal Polarity through Local Phosphorylation of Stathmin/Op18 [1].
Our findings unveil a pathway linking the Rac activator DOCK7 to a microtubule regulatory protein and highlight the contribution of microtubule network regulation to axon development [1].
In addition, we identified three TSC1-TSC2 interacting proteins, including DOCK7 a putative rhebGEF [2].

Physical interactions of DOCK7

We further demonstrate that DOCK7 and Rac activation lead to phosphorylation and inactivation of the microtubule destabilizing protein stathmin/Op18 in the nascent axon and that this event is important for axon development [1].

References

The Rac Activator DOCK7 Regulates Neuronal Polarity through Local Phosphorylation of Stathmin/Op18. Watabe-Uchida, M., John, K.A., Janas, J.A., Newey, S.E., Van Aelst, L. Neuron (2006) [Pubmed]
Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. Nellist, M., Burgers, P.C., van den Ouweland, A.M., Halley, D.J., Luider, T.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP010192	Anopheles gambiae str. PEST
SPK1	Arabidopsis thaliana
DOCK7	Bos taurus
F46H5.4	Caenorhabditis elegans
DOCK7	Canis lupus familiaris
dock7	Danio rerio
Zir	Drosophila melanogaster
DOCK7	Gallus gallus
DOCK7	Macaca mulatta
Dock7	Mus musculus
Dock7	Rattus norvegicus
dock6	Xenopus (Silurana) tropicalis

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