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Chemical Compound Review

Neuronal     2-bromo-2-ethyl-butanamide

Synonyms: Carbromide, Carabromide, NSC-4607, AG-F-72828, C6H12BrNO, ...
 
 
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Disease relevance of Diethylbromoacetamide

  • When combined, hypoxia and etoposide cooperated in abolishing the N cell generation and promoting the conversion of the tumor described [1].
  • Subclones of neuronal (N) and non-neuronal (S) cells established from neuroblastoma tumors cultured in vitro differ in their growth characteristics and N-myc expression [2].
  • Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy [3].
  • AIMS/HYPOTHESIS: Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes [4].
  • NeuN staining and terminal deoxynucleotidyl dUTP nick-end labeling staining showed no neuronal cell loss around the SVZ, and in the RMS and the OB after transient ischemia [5].
 

Psychiatry related information on Diethylbromoacetamide

  • 2 Selective Neuronal Degeneration in Huntington's Disease [6].
  • CONCLUSION: Neuronal COX-2 content in subsets of hippocampal pyramidal neurons may be an indicator of progression of dementia in early AD [7].
  • Physiological basis of feeding behavior in Tritonia diomedea. II. Neuronal mechanisms [8].
  • 6. Neuronal response to receptive field brushing was observed in 15 neurons during REM sleep [9].
  • Assembly of proteins and peptides into amyloid fibrils is characteristic of the pathology of a number of degenerative diseases, of which perhaps the best known is Alzheimer's. Neuronal death in Alzheimer's disease has been linked to aggregation of beta-amyloid peptide and deposition of the aggregates in brain tissue [10].
 

High impact information on Diethylbromoacetamide

 

Chemical compound and disease context of Diethylbromoacetamide

 

Biological context of Diethylbromoacetamide

  • Cadherins are a family of intercellular glycoproteins responsible for calcium-dependent cell adhesion and are currently divided into four types: epithelial (E), neuronal (N), placental (P), and vascular (V) [21].
  • 8. Neuronal and glial death was a function of both the degree and the duration of intracellular acidification, such that the LD50 following timed exposure to HCl increased from pH, 3.5 for 10-min acid incubations to pHi 5.9 for 2-hr exposures and pHi 6.5 for 6-hr exposures [22].
  • Glucocorticoid Modulatory Element-binding Protein 1 Binds to Initiator Procaspases and Inhibits Ischemia-induced Apoptosis and Neuronal Injury [23].
  • BM88 Is a Dual Function Molecule Inducing Cell Cycle Exit and Neuronal Differentiation of Neuroblastoma Cells via Cyclin D1 Down-regulation and Retinoblastoma Protein Hypophosphorylation [24].
  • M. Le Douarin, (1984) In Cellular and Molecular Biology of Neuronal Development (I. Black, Ed.), pp [25].
 

Anatomical context of Diethylbromoacetamide

  • Studies on the control of myelinogenesis. IV. Neuronal induction of Schwann cell myelin-specific protein synthesis during nerve fiber regeneration [26].
  • During grooming behavior, rats emit complex but highly predictable species-specific sequences of movements, termed "syntactic chains." Neuronal activity of 41% of cells in the dorsolateral and ventromedial neostriatum coded the sequential pattern of syntactic chains [27].
  • Spinocerebellar Ataxia Type 3 (SCA3): Thalamic Neurodegeneration Occurs Independently from Thalamic Ataxin-3 Immunopositive Neuronal Intranuclear Inclusions [28].
  • N (W-N) cells derived from the NBL-W cell line express 5-fold higher levels of N-myc mRNA and 10-12-fold higher levels of protein than S cells (W-S), despite having the same N-myc copy number [2].
  • Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes [29].
 

Associations of Diethylbromoacetamide with other chemical compounds

  • Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats [30].
  • METHODS: Neuronal survival was measured in mixed retinal cell cultures treated for 24 hours with media containing 100 microM glutamate, with or without the addition of each of the drugs (1-1000 microM) [31].
  • 1. Neuronal nicotinic acetylcholine receptors in slices of rat medial habenula were studied using patch clamp recording techniques [32].
  • A Novel Forward Genetic Screen for Identifying Mutations Affecting Larval Neuronal Dendrite Development in Drosophila melanogaster [33].
  • At least 1 month after infusion ended, brains were processed immunocytochemically using antibodies to BrdU, a neuronal nuclear protein (NeuN), or calbindin D28K (CaBP), which labels mature granule cells [34].
 

Gene context of Diethylbromoacetamide

  • Retinal pathology and function in a Cln3 knockout mouse model of juvenile Neuronal Ceroid Lipofuscinosis (batten disease) [35].
  • This issue of Peptides was inspired by a gathering of CCK researchers at the first Neuronal Cholecsytokinin Gordon Conference. The papers in this issue reflect the diversity of CCK research and demonstrate how the field has matured [36].
  • Neuronal Differentiation Is Accompanied by Increased Levels of SNAP-25 Protein in Fetal Rat Primary Cortical Neurons: Implications in Neuronal Plasticity and Alzheimer's Disease [37].
  • Seizures rapidly induced cleavage of constitutively expressed caspase-6, followed by elevated VEIDase activity and the proteolysis of lamin A. Neuronal caspase-6 immunoreactivity was markedly upregulated within cortex and hippocampus in relation to bursts of polyspike paroxysmal discharges [38].
  • Immunocytochemical localization of Fos was used as our metric for "sound activation." Neuronal types upregulating Fos expression in response to sound stimulation were further identified with Nissl counterstaining [39].
 

Analytical, diagnostic and therapeutic context of Diethylbromoacetamide

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  24. BM88 Is a Dual Function Molecule Inducing Cell Cycle Exit and Neuronal Differentiation of Neuroblastoma Cells via Cyclin D1 Down-regulation and Retinoblastoma Protein Hypophosphorylation. Georgopoulou, N., Hurel, C., Politis, P.K., Gaitanou, M., Matsas, R., Thomaidou, D. J. Biol. Chem. (2006) [Pubmed]
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  27. Coding of serial order by neostriatal neurons: a "natural action" approach to movement sequence. Aldridge, J.W., Berridge, K.C. J. Neurosci. (1998) [Pubmed]
  28. Spinocerebellar Ataxia Type 3 (SCA3): Thalamic Neurodegeneration Occurs Independently from Thalamic Ataxin-3 Immunopositive Neuronal Intranuclear Inclusions. Rüb, U., de Vos, R.A., Brunt, E.R., Sebestény, T., Schöls, L., Auburger, G., Bohl, J., Ghebremedhin, E., Gierga, K., Seidel, K., den Dunnen, W., Heinsen, H., Paulson, H., Deller, T. Brain Pathol. (2006) [Pubmed]
  29. Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. Velaz-Faircloth, M., Guadaño-Ferraz, A., Henzi, V.A., Fremeau, R.T. J. Biol. Chem. (1995) [Pubmed]
  30. Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats. Doyon, C., Denis, R.G., Baraboi, E.D., Samson, P., Lalonde, J., Deshaies, Y., Richard, D. Diabetes (2006) [Pubmed]
  31. Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina. Baptiste, D.C., Hartwick, A.T., Jollimore, C.A., Baldridge, W.H., Chauhan, B.C., Tremblay, F., Kelly, M.E. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
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  34. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Scharfman, H., Goodman, J., Macleod, A., Phani, S., Antonelli, C., Croll, S. Exp. Neurol. (2005) [Pubmed]
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  38. Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Henshall, D.C., Skradski, S.L., Meller, R., Araki, T., Minami, M., Schindler, C.K., Lan, J.Q., Bonislawski, D.P., Simon, R.P. Neurobiol. Dis. (2002) [Pubmed]
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