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Gene Review

KIN4  -  Kin4p

Saccharomyces cerevisiae S288c

Synonyms: KIN3, KIN31, O5220, Serine/threonine-protein kinase KIN4, YOR233W
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High impact information on KIN4

  • KIN4 prevents exit from mitosis in cells with mispositioned nuclei by inhibiting the mitotic exit network (MEN), a GTPase signaling cascade that promotes exit from mitosis [1].
  • When spindles are correctly oriented, Kin4 and Bub2-Bfa1 are asymmetrically localized to opposite spindle pole bodies (SPBs) [2].
  • Here, we show that the Kin4 kinase is a component of the SPOC and as such is essential to delay cell cycle progression of cells with a misaligned spindle [2].
  • Kin4 is active in cells with mispositioned nuclei and predominantly localizes to mother cells, where it is ideally situated to inhibit MEN signaling at spindle pole bodies (SPBs) when anaphase spindle elongation occurs within the mother cell [1].


  1. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. D'Aquino, K.E., Monje-Casas, F., Paulson, J., Reiser, V., Charles, G.M., Lai, L., Shokat, K.M., Amon, A. Mol. Cell (2005) [Pubmed]
  2. Kin4 kinase delays mitotic exit in response to spindle alignment defects. Pereira, G., Schiebel, E. Mol. Cell (2005) [Pubmed]
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