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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HELZ2  -  helicase with zinc finger 2,...

Homo sapiens

Synonyms: ATP-dependent helicase PRIC285, Helicase with zinc finger 2, transcriptional coactivator, Helicase with zinc finger domain 2, KIAA1769, PDIP-1, ...
 
 
 
 
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High impact information on PRIC285

  • PDIP1alpha also enhanced estrogen receptoralpha- and androgen receptor-mediated transactivation, whereas PDIP1beta did not [1].
  • We also identified the expression of the N terminal extended form of PDIP1alpha (referred to as PDIP1beta) consisting of 2649 amino acids (295 kDa) in human cultured cell lines by RT-PCR, and 5' rapid amplification of cDNA ends [1].
  • Using the DNA-binding domain (DBD) and hinge region of human peroxisome proliferator-activated receptor (PPAR)-gamma as bait in yeast two-hybrid screen, we isolated partial cDNA identical with that of the C terminal of KIAA1769 [1].

References

  1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Tomaru, T., Satoh, T., Yoshino, S., Ishizuka, T., Hashimoto, K., Monden, T., Yamada, M., Mori, M. Endocrinology (2006) [Pubmed]
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