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CGGBP1  -  CGG triplet repeat binding protein 1

Homo sapiens

Synonyms: 20 kDa CGG-binding protein, CGG triplet repeat-binding protein 1, CGG-binding protein 1, CGGBP, p20-CGGBP, ...
 
 
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High impact information on CGGBP1

  • Previous reports have described the human DNA CGG repeat-binding protein (CGGBP1 or p20), which binds specifically to nonmethylated, but not to methylated, 5'-(CGG)(n)-3' repeats in the promoter of the fragile X mental retardation 1 (FMR1) gene [1].
  • We have recently described the isolation of a protein p20-CGGBP that binds sequence-specifically to the double-stranded trinucleotide repeat 5'-d(CGG)-3' (Deissler, H., Behn-Krappa, A., and Doerfler, W. (1996) J. Biol. Chem. 271, 4327-4334) [2].
  • Peptide sequence tags of p20-CGGBP obtained by nanoelectrospray mass spectrometry were screened against an expressed sequence tag data base, retrieving a clone that contained the full-length coding sequence for p20-CGGBP [2].
  • A sequence of 235 nucleotides 5' upstream of CGGBP1 is essential for promoter activity in transfection experiments [3].
  • The genomic and mRNA organization of the human and murine CGGBP1 genes was studied and the human gene was mapped to chromosome 3p [3].
 

Physical interactions of CGGBP1

  • Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene [2].
 

Regulatory relationships of CGGBP1

  • The human nuclear 5'-(CGG)(n)-3'-binding protein (CGGBP1) influences the expression of the fragile X mental retardation (FMR1) gene by specifically interacting with the 5'-(CGG)(n>5)-3' repeat in its 5' untranslated region [3].

References

  1. The human 20-kDa 5'-(CGG)(n)-3'-binding protein is targeted to the nucleus and affects the activity of the FMR1 promoter. Müller-Hartmann, H., Deissler, H., Naumann, F., Schmitz, B., Schröer, J., Doerfler, W. J. Biol. Chem. (2000) [Pubmed]
  2. Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene. Deissler, H., Wilm, M., Genç, B., Schmitz, B., Ternes, T., Naumann, F., Mann, M., Doerfler, W. J. Biol. Chem. (1997) [Pubmed]
  3. Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1). Naumann, F., Remus, R., Schmitz, B., Doerfler, W. Genomics (2004) [Pubmed]
 
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