The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

SNL1  -  Snl1p

Saccharomyces cerevisiae S288c

Synonyms: HSP70 co-chaperone SNL1, Suppressor of NUP116-C lethal, YIL016W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SNL1

  • In live yeast, mutated Snl1p could not substitute for wild-type Snl1p in suppressing the lethal defect caused by truncation of the Nup116p nuclear pore component [1].
  • Point mutations in Snl1p that disrupted the conserved residues Glu-112 and Arg-141, equivalent to Glu-212 and Arg-237 in Bag-1M, abolished the interaction with Hsp70 proteins [1].
  • Thus, Snl1p is the first Bag domain protein identified in S. cerevisiae, and its interaction with Hsp70 is essential for biological activity [1].
  • Snl1p has a predicted molecular mass of 18.3 kDa, a putative transmembrane domain, and limited sequence similarity to Pom152p, the only previously identified yeast NPC-associated integral membrane protein [2].
  • The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function [2].

Anatomical context of SNL1


  1. Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae. Sondermann, H., Ho, A.K., Listenberger, L.L., Siegers, K., Moarefi, I., Wente, S.R., Hartl, F.U., Young, J.C. J. Biol. Chem. (2002) [Pubmed]
  2. The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function. Ho, A.K., Raczniak, G.A., Ives, E.B., Wente, S.R. Mol. Biol. Cell (1998) [Pubmed]
WikiGenes - Universities