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Gene Review

ARG81  -  Arg81p

Saccharomyces cerevisiae S288c

Synonyms: ARGR2, Arginine metabolism regulation protein II, Arginine-requiring protein 81, YML099C
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High impact information on ARG81

  • By contrast, the recruitment of Arg81p and Arg82p was stimulated by exogenous arginine [1].
  • Arg80 and Mcm1, two members of the MADS box family of DNA-binding proteins, regulate the metabolism of arginine in association with Arg81, the arginine sensor [2].
  • The UASI-protein complex was also observed even when extracts were derived from arg80/argRI or arg81/argRII deletion mutants [3].
  • Furthermore, the same assays using a Rab5b R81A substitution mutant showed that the Arg81 in the Switch II region [the second GTP/GDP binding motif (residues 74-93)] was essential for Rab5b dimerization [4].

Associations of ARG81 with chemical compounds

  • This operator mutation helps to define a negative mode of control of the synthesis of the arginine biosynthetic enzymes, as had been suggested earlier upon the isolation of argRI- (arg80), argRII- (arg81), and argRIII- (arg82) specific regulatory mutations [5].

Other interactions of ARG81

  • Many of these residues are clustered on one side of the protein, which could serve as an interface for interaction with Arg81 or Mcm1 [2].


  1. Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism. Yoon, S., Govind, C.K., Qiu, H., Kim, S.J., Dong, J., Hinnebusch, A.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Swapping functional specificity of a MADS box protein: residues required for Arg80 regulation of arginine metabolism. Jamai, A., Dubois, E., Vershon, A.K., Messenguy, F. Mol. Cell. Biol. (2002) [Pubmed]
  3. Tripartite structure of the Saccharomyces cerevisiae arginase (CAR1) gene inducer-responsive upstream activation sequence. Viljoen, M., Kovari, L.Z., Kovari, I.A., Park, H.D., van Vuuren, H.J., Cooper, T.G. J. Bacteriol. (1992) [Pubmed]
  4. Dimerization of small GTPase Rab5. Daitoku, H., Isida, J., Fujiwara, K., Nakajima, T., Fukamizu, A. Int. J. Mol. Med. (2001) [Pubmed]
  5. Regulation of arginine biosynthesis in Saccharomyces cerevisiae: isolation of a cis-dominant, constitutive mutant for ornithine carbamoyltransferase synthesis. Messenguy, F. J. Bacteriol. (1976) [Pubmed]
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