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Gene Review

ARG80  -  Arg80p

Saccharomyces cerevisiae S288c

Synonyms: ARGR1, Arginine metabolism regulation protein I, Arginine-requiring protein 80, YM9532.07, YMR042W
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Disease relevance of ARG80


High impact information on ARG80

  • Furthermore, we show that like p62TCF, Elk-1 forms complexes with the yeast SRF-homologue MCM1 but not with yeast ARG80 [2].
  • ARG80 and Agamous exhibit similar DNA binding specificities but do not interact with either STE12 or p62TCF [3].
  • Through the analysis of promoter constructs with ARC deleted and an arg80 rad6 double mutant, we show that Rad6 repression is mediated through the ArgR/Mcm1 complex [4].
  • Swapping functional specificity of a MADS box protein: residues required for Arg80 regulation of arginine metabolism [5].
  • It remains functional if the TATA box is moved downstream of it but becomes inoperative in repression when displaced to a far-upstream position where it mediates an arginine and ARGR-dependent induction of gene expression [6].

Biological context of ARG80


Associations of ARG80 with chemical compounds

  • We show here that Mcm1p and Arg80p chaperoning by Arg82p does not involve the inositol polyphosphate kinase activity of Arg82p, but requires its polyaspartate domain [9].

Physical interactions of ARG80

  • With the support of chromatin IP chip data, we also predict a possible variant of the Swi4 binding motif and recover a core motif for Arg80 [10].

Regulatory relationships of ARG80

  • Arg82p also controls expression of arginine-responsive genes by interacting with Arg80p and Mcm1p, and expression of Mcm1-dependent genes by interacting with Mcm1p [9].

Other interactions of ARG80

  • The UASI-protein complex was also observed even when extracts were derived from arg80/argRI or arg81/argRII deletion mutants [11].
  • In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter [12].
  • Sequences in and around BoxA are necessary for ARGR binding to these four promoters in vitro, whereas sequences in and around BoxB are clearly protected against DNase I digestion only for CAR1 [13].
  • A similar analysis of expression of the gene CPA1, for which a translational regulation by arginine has been clearly demonstrated (M. Werner, A. Feller, F. Messenguy, and A. Piérard, Cell 49:805-813, 1987), indicates that this gene is also partly regulated at the transcriptional level by the ARGR repressor system [14].

Analytical, diagnostic and therapeutic context of ARG80


  1. Regulation of arginine metabolism in Saccharomyces cerevisiae: expression of the three ARGR regulatory genes and cellular localization of their products. Bercy, J., Dubois, E., Messenguy, F. Gene (1987) [Pubmed]
  2. Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Hipskind, R.A., Rao, V.N., Mueller, C.G., Reddy, E.S., Nordheim, A. Nature (1991) [Pubmed]
  3. A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formation. Mueller, C.G., Nordheim, A. EMBO J. (1991) [Pubmed]
  4. The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcription. Turner, S.D., Ricci, A.R., Petropoulos, H., Genereaux, J., Skerjanc, I.S., Brandl, C.J. Mol. Cell. Biol. (2002) [Pubmed]
  5. Swapping functional specificity of a MADS box protein: residues required for Arg80 regulation of arginine metabolism. Jamai, A., Dubois, E., Vershon, A.K., Messenguy, F. Mol. Cell. Biol. (2002) [Pubmed]
  6. Characterization of the DNA target site for the yeast ARGR regulatory complex, a sequence able to mediate repression or induction by arginine. De Rijcke, M., Seneca, S., Punyammalee, B., Glansdorff, N., Crabeel, M. Mol. Cell. Biol. (1992) [Pubmed]
  7. Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MAT alpha cells. Passmore, S., Maine, G.T., Elble, R., Christ, C., Tye, B.K. J. Mol. Biol. (1988) [Pubmed]
  8. Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript. Boonchird, C., Messenguy, F., Dubois, E. Mol. Gen. Genet. (1991) [Pubmed]
  9. Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. El Alami, M., Messenguy, F., Scherens, B., Dubois, E. Mol. Microbiol. (2003) [Pubmed]
  10. Transcription factor binding element detection using functional clustering of mutant expression data. Chen, G., Hata, N., Zhang, M.Q. Nucleic Acids Res. (2004) [Pubmed]
  11. Tripartite structure of the Saccharomyces cerevisiae arginase (CAR1) gene inducer-responsive upstream activation sequence. Viljoen, M., Kovari, L.Z., Kovari, I.A., Park, H.D., van Vuuren, H.J., Cooper, T.G. J. Bacteriol. (1992) [Pubmed]
  12. In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter. Dubois, E., Messenguy, F. Mol. Cell. Biol. (1991) [Pubmed]
  13. Determination of the DNA-binding sequences of ARGR proteins to arginine anabolic and catabolic promoters. Messenguy, F., Dubois, E., Boonchird, C. Mol. Cell. Biol. (1991) [Pubmed]
  14. Arginine-specific repression in Saccharomyces cerevisiae: kinetic data on ARG1 and ARG3 mRNA transcription and stability support a transcriptional control mechanism. Crabeel, M., Lavalle, R., Glansdorff, N. Mol. Cell. Biol. (1990) [Pubmed]
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