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Gene Review

ARG82  -  inositol polyphosphate multikinase

Saccharomyces cerevisiae S288c

Synonyms: ARGR3, Arginine metabolism regulation protein III, IPK2, IPMK, Inositol polyphosphate multikinase, ...
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High impact information on ARG82


Biological context of ARG82


Anatomical context of ARG82


Associations of ARG82 with chemical compounds

  • Collectively our results provide a molecular basis for the synthesis of higher inositol polyphosphates in plants through multiple routes and indicate that the 6-/3-/5-kinase activities found in plant extracts may be encoded by the IPK2 gene class [5].
  • Expression of either I(1,4,5)P3 6- or 3-kinase activity rescued growth of ipk2-deficient yeast at high temperatures, whereas only 6-kinase activity enabled growth on ornithine as the sole nitrogen source [10].
  • Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae [11].
  • Inositol triphosphate (IP(3)) in yeast is rapidly transformed into IP(4) and IP(5) by a dual kinase, Arg82 [12].
  • In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase [9].

Other interactions of ARG82

  • We show here that Mcm1p and Arg80p chaperoning by Arg82p does not involve the inositol polyphosphate kinase activity of Arg82p, but requires its polyaspartate domain [8].
  • Heterologous expression of dmIpk2, but not dmIP3K, in ipk2 mutant yeast recapitulates phospholipase C-dependent cellular synthesis of IP6 [13].

Analytical, diagnostic and therapeutic context of ARG82


  1. A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Odom, A.R., Stahlberg, A., Wente, S.R., York, J.D. Science (2000) [Pubmed]
  2. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Resnick, A.C., Snowman, A.M., Kang, B.N., Hurt, K.J., Snyder, S.H., Saiardi, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism. Yoon, S., Govind, C.K., Qiu, H., Kim, S.J., Dong, J., Hinnebusch, A.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity. Holmes, W., Jogl, G. J. Biol. Chem. (2006) [Pubmed]
  5. Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. Stevenson-Paulik, J., Odom, A.R., York, J.D. J. Biol. Chem. (2002) [Pubmed]
  6. A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. Fujii, M., York, J.D. J. Biol. Chem. (2005) [Pubmed]
  7. Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast. Perera, N.M., Michell, R.H., Dove, S.K. J. Biol. Chem. (2004) [Pubmed]
  8. Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. El Alami, M., Messenguy, F., Scherens, B., Dubois, E. Mol. Microbiol. (2003) [Pubmed]
  9. Regulation of chromatin remodeling by inositol polyphosphates. Steger, D.J., Haswell, E.S., Miller, A.L., Wente, S.R., O'Shea, E.K. Science (2003) [Pubmed]
  10. Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae. Seeds, A.M., Bastidas, R.J., York, J.D. J. Biol. Chem. (2005) [Pubmed]
  11. Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae. Auesukaree, C., Tochio, H., Shirakawa, M., Kaneko, Y., Harashima, S. J. Biol. Chem. (2005) [Pubmed]
  12. Evidence for inositol triphosphate as a second messenger for glucose-induced calcium signalling in budding yeast. Tisi, R., Belotti, F., Wera, S., Winderickx, J., Thevelein, J.M., Martegani, E. Curr. Genet. (2004) [Pubmed]
  13. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds, A.M., Sandquist, J.C., Spana, E.P., York, J.D. J. Biol. Chem. (2004) [Pubmed]
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