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Gene Review

CTK3  -  Ctk3p

Saccharomyces cerevisiae S288c

Synonyms: CTD kinase 32 kDa subunit, CTD kinase subunit 3, CTD kinase subunit gamma, CTDK-I gamma subunit, YM8339.07, ...
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High impact information on CTK3

  • Ctk1 is a Saccharomyces cerevisiae cyclin-dependent protein kinase (CDK) that assembles with Ctk2 and Ctk3 to form an active protein kinase complex, CTDK-I [1].
  • It is composed of three polypeptides: Ctk1p and Ctk2p, a cyclin-dependent kinase and a C-type cyclin subunit, respectively; and Ctk3p, a third subunit of unknown function [2].

Biological context of CTK3


Other interactions of CTK3

  • The CTK2 gene encodes a cyclin-related protein with limited homology to cyclin C, while CTK3 shows no similarity to other known proteins [4].
  • We have now cloned the genes for the two smaller kinase subunits, CTK2 and CTK3, and found that they form a unique, divergent cyclin-cyclin-dependent kinase complex with the previously characterized largest subunit protein CTK1, a cyclin-dependent kinase homolog [4].


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