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Gene Review:

CTK3 - Ctk3p

Saccharomyces cerevisiae S288c

Synonyms: CTD kinase 32 kDa subunit, CTD kinase subunit 3, CTD kinase subunit gamma, CTDK-I gamma subunit, YM8339.07, ...

Sterner, D.E. et al., Hautbergue, G. et al., Ostapenko, D. et al., Ostapenko, D. et al.

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High impact information on CTK3

Ctk1 is a Saccharomyces cerevisiae cyclin-dependent protein kinase (CDK) that assembles with Ctk2 and Ctk3 to form an active protein kinase complex, CTDK-I [1].
It is composed of three polypeptides: Ctk1p and Ctk2p, a cyclin-dependent kinase and a C-type cyclin subunit, respectively; and Ctk3p, a third subunit of unknown function [2].

Biological context of CTK3

Mutations in CTDK-I subunits-Ctk1p, Ctk2p, and Ctk3p-confer conditional phenotypes [3].

Other interactions of CTK3

The CTK2 gene encodes a cyclin-related protein with limited homology to cyclin C, while CTK3 shows no similarity to other known proteins [4].
We have now cloned the genes for the two smaller kinase subunits, CTK2 and CTK3, and found that they form a unique, divergent cyclin-cyclin-dependent kinase complex with the previously characterized largest subunit protein CTK1, a cyclin-dependent kinase homolog [4].

References

Phosphorylation by Cak1 regulates the C-terminal domain kinase Ctk1 in Saccharomyces cerevisiae. Ostapenko, D., Solomon, M.J. Mol. Cell. Biol. (2005) [Pubmed]
The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway. Hautbergue, G., Goguel, V. Mol. Cell. Biol. (1999) [Pubmed]
Budding yeast CTDK-I is required for DNA damage-induced transcription. Ostapenko, D., Solomon, M.J. Eukaryotic Cell (2003) [Pubmed]
The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Sterner, D.E., Lee, J.M., Hardin, S.E., Greenleaf, A.L. Mol. Cell. Biol. (1995) [Pubmed]

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AGOS_ABL130C	Ashbya gossypii ATCC 10895
KLLA0D01815g	Kluyveromyces lactis NRRL Y-1140

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