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Gene Review:

CTK2 - Ctk2p

Saccharomyces cerevisiae S288c

Synonyms: CTD kinase 38 kDa subunit, CTD kinase subunit 2, CTD kinase subunit beta, CTDK-I subunit beta, J1390, ...

Hautbergue, G. et al., Ostapenko, D. et al., Sterner, D.E. et al., Ostapenko, D. et al.

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High impact information on CTK2

Ctk1 is a Saccharomyces cerevisiae cyclin-dependent protein kinase (CDK) that assembles with Ctk2 and Ctk3 to form an active protein kinase complex, CTDK-I [1].
Strikingly, neither phosphorylation nor destruction of Ctk2p requires its associated kinase Ctk1p, a feature fundamentally different from that which has been observed for cell cycle cyclins [2].
Surprisingly, unlike what has been described for cell cycle cyclins, steady-state levels of Ctk2p are composed of two relatively abundant forms, one of them phosphorylated [2].

Biological context of CTK2

Mutations in CTDK-I subunits-Ctk1p, Ctk2p, and Ctk3p-confer conditional phenotypes [3].

Other interactions of CTK2

The CTK2 gene encodes a cyclin-related protein with limited homology to cyclin C, while CTK3 shows no similarity to other known proteins [4].

References

Phosphorylation by Cak1 regulates the C-terminal domain kinase Ctk1 in Saccharomyces cerevisiae. Ostapenko, D., Solomon, M.J. Mol. Cell. Biol. (2005) [Pubmed]
The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway. Hautbergue, G., Goguel, V. Mol. Cell. Biol. (1999) [Pubmed]
Budding yeast CTDK-I is required for DNA damage-induced transcription. Ostapenko, D., Solomon, M.J. Eukaryotic Cell (2003) [Pubmed]
The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Sterner, D.E., Lee, J.M., Hardin, S.E., Greenleaf, A.L. Mol. Cell. Biol. (1995) [Pubmed]

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AGOS_ACR041W	Ashbya gossypii ATCC 10895
KLLA0D09482g	Kluyveromyces lactis NRRL Y-1140

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