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Gene Review:

SPT21 - Spt21p

Saccharomyces cerevisiae S288c

Synonyms: Protein SPT21, YM8010.09, YMR179W

Hess, D. et al., Hess, D. et al., Natsoulis, G. et al.

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High impact information on SPT21

Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21 [1].
These results, taken together with the identification of spt10 mutations that suppress an spt21Delta mutation, suggest a model for transcriptional activation by Spt10 and Spt21 [1].

Biological context of SPT21

Mutations in SPT10 and SPT21 of Saccharomyces cerevisiae have been previously shown to cause two prominent mutant phenotypes: (1) defects in transcription of particular histone genes and (2) suppression of Ty and delta-insertion mutations (Spt(-) phenotype) [2].
We have isolated mutations that fall into two genes, SPT10 and SPT21, that allow the 3' LTRs of Ty1 elements inserted at various positions in the genome of Saccharomyces cerevisiae to act as promoters [3].

Analytical, diagnostic and therapeutic context of SPT21

Previous studies have demonstrated that Spt10 and Spt21 are required for the normal transcription of a subset of the histone genes in Saccharomyces cerevisiae, and sequence analysis has suggested that Spt10 is an acetyltransferase [1].

References

Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21. Hess, D., Liu, B., Roan, N.R., Sternglanz, R., Winston, F. Mol. Cell. Biol. (2004) [Pubmed]
Evidence that Spt10 and Spt21 of Saccharomyces cerevisiae play distinct roles in vivo and functionally interact with MCB-binding factor, SCB-binding factor and Snf1. Hess, D., Winston, F. Genetics (2005) [Pubmed]
The products of the SPT10 and SPT21 genes of Saccharomyces cerevisiae increase the amplitude of transcriptional regulation at a large number of unlinked loci. Natsoulis, G., Dollard, C., Winston, F., Boeke, J.D. New Biol. (1991) [Pubmed]

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AGOS_AFL132C	Ashbya gossypii ATCC 10895
KLLA0C16093g	Kluyveromyces lactis NRRL Y-1140

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