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Gene Review

DSK2  -  Dsk2p

Saccharomyces cerevisiae S288c

Synonyms: SHE4, Ubiquitin domain-containing protein DSK2, YM8021.02, YMR276W
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High impact information on DSK2

  • Ubiquitin-like (UBL)-ubiquitin-associated (UBA) proteins such as Rad23 and Dsk2 mediate the delivery of polyubiquitinated proteins to the proteasome in the ubiquitin-proteasome pathway [1].
  • Dsk2p is a nuclear-enriched protein, and we propose that Dsk2p assists in Cdc31 assembly into the new SPB [2].
  • Suppressors of a kar1 allele defective for SPB duplication were isolated in two genes, CDC31 and DSK2 (Vallen, E.A., W.H., M. Winey, and M.D. Rose. 1994. Genetics. 137:407-422) [2].
  • Therefore, DSK2 does not act by interfering with ubiquitin-dependent protein degradation of these proteins [2].
  • Unlike ubiquitin, the NH2-terminal domain of Dsk2p is not cleaved from the protein, indicating that Dsk2p is not conjugated to other proteins [2].

Biological context of DSK2


Associations of DSK2 with chemical compounds

  • To elucidate the role of DSK2 in SPB duplication, we cloned the gene and found it encodes a novel ubiquitin-like protein containing an NH2 terminus 36% identical to ubiquitin [2].

Physical interactions of DSK2


Other interactions of DSK2

  • Although DSK2 is not essential, a strain deleted for both DSK2 and RAD23 is temperature sensitive for growth due to a block in SPB duplication [2].


  1. Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. Ishii, T., Funakoshi, M., Kobayashi, H. EMBO J. (2006) [Pubmed]
  2. Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center. Biggins, S., Ivanovska, I., Rose, M.D. J. Cell Biol. (1996) [Pubmed]
  3. Genetic interactions between CDC31 and KAR1, two genes required for duplication of the microtubule organizing center in Saccharomyces cerevisiae. Vallen, E.A., Ho, W., Winey, M., Rose, M.D. Genetics (1994) [Pubmed]
  4. Yeast UBL-UBA proteins have partially redundant functions in cell cycle control. D??az-Mart??nez, L.A., Kang, Y., Walters, K.J., Clarke, D.J. Cell division (2006) [Pubmed]
  5. Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition. Ohno, A., Jee, J., Fujiwara, K., Tenno, T., Goda, N., Tochio, H., Kobayashi, H., Hiroaki, H., Shirakawa, M. Structure (Camb.) (2005) [Pubmed]
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