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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Genetics


Psychiatry related information on Genetics


High impact information on Genetics


Chemical compound and disease context of Genetics


Biological context of Genetics

  • Through the systematic use of genetics, biochemistry, molecular biology and cell biology, they have identified a complex set of interacting molecules that work coordinately to regulate cholesterol import and synthesis [21].
  • Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and the toxic peptide generated by its cleavage, beta-amyloid (Abeta) [22].
  • In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours [23].
  • Temporal aspects of antigen exposure, antigen processing of specific peptide antigens, and the interplay between specific antigens, MHC genetics, and host T-cell responses remain to be explored [24].
  • The power of lac genetics can be applied to almost any bacterial system with gene fusions that hook any gene of interest to lacZ, which is the structural gene that encodes beta-galactosidase [25].

Anatomical context of Genetics

  • The genetics of the protein 4.1 family: organizers of the membrane and cytoskeleton [26].
  • Here we combine genetics and cell biology to identify genes that control the polarized distribution of actin filaments within the Drosophila follicular epithelium [27].
  • Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC) [28].
  • Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep [29].
  • Although, in principle, transposition may occur in any cell type, expression and transposition of a full-length functional element in the germ line are necessary to explain the evolutionary genetics of L1 [30].

Associations of Genetics with chemical compounds

  • Genetics and insurance in Britain: why more than just the Atlantic divides the English-speaking nations [31].
  • Evolutionary genetics. Siberian mice upset Mendel [32].
  • The huntingtin gene product is expressed at similar levels in patients and controls, and the genetics of the disorder suggest that the expansion of the polyglutamine repeat induces a toxic gain of function, perhaps through interactions with other cellular proteins [33].
  • Genetics of chloroquine resistance in malaria parasites [34].
  • Genetics and Medicine: an evolving relationship [35].

Gene context of Genetics

  • Using mouse genetics, we find that Pten and Tsc2 act synergistically to suppress the severity of a subset of tumors specific to loss of each of these genes [36].
  • Genetics has revealed three additional genes, staufen, vasa, and tudor, that are also essential for pole plasm formation [37].
  • These results, coupled with the closely controlled genetics of this study, indicate that reductions in the expression of P-selectin, ICAM-1, or E-selectin provide direct protection from atherosclerotic lesion formation in this model [38].
  • CBX7 does not inter-function or colocalize with Bmi1, and both can exert their actions independently of each other as shown by reverse genetics [39].
  • Here we review recent developments in the analysis of Mitf function in vivo and in vitro and show how traditional genetics, modern forward genetics and in vitro biochemical analyses have combined to produce an intriguing story on the role and actions of a gene family in a living organism [40].

Analytical, diagnostic and therapeutic context of Genetics


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