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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RIT1  -  Rit1p

Saccharomyces cerevisiae S288c

Synonyms: Initiator tRNA phosphoribosyl-transferase, YM8021.09C, YMR283C, tRNA A64-2'-O-ribosylphosphate transferase
 
 
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High impact information on RIT1

  • These findings suggest that, in typical agricultural soils, RIT1 functions primarily as a high-affinity Fe(2+) transporter that mediates root Fe acquisition [1].
  • However, the ability of RIT1 to facilitate Zn and Cd uptake when these metals are present at elevated concentrations suggests that RIT1 may be one pathway for the entry of toxic metals into the food chain [1].
  • The Saccharomyces cerevisiae gene RIT1 encodes a phospho-ribosyl transferase that exclusively modifies the initiator tRNA (tRNAMet(i)) by the addition of a 2'-O-ribosyl phosphate group to Adenosine 64 [2].

References

  1. Kinetic properties of a micronutrient transporter from Pisum sativum indicate a primary function in Fe uptake from the soil. Cohen, C.K., Garvin, D.F., Kochian, L.V. Planta (2004) [Pubmed]
  2. Genetic interactions between a null allele of the RIT1 gene encoding an initiator tRNA-specific modification enzyme and genes encoding translation factors in Saccharomyces cerevisiae. Aström, S.U., Nordlund, M.E., Erickson, F.L., Hannig, E.M., Byström, A.S. Mol. Gen. Genet. (1999) [Pubmed]
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