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Gene Review

PFA3  -  Pfa3p

Saccharomyces cerevisiae S288c

Synonyms: N0325, Palmitoyltransferase PFA3, Protein fatty acyltransferase 3, YNL326C
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High impact information on PFA3

  • Here we demonstrate that the DHHC-CRD proteins Pfa3p (protein fatty acyltransferase 3, encoded by YNL326c) and Swf1p are important for vacuole fusion [1].
  • The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p [1].
  • Cells lacking Pfa3p had fragmented vacuoles when stressed, and cells lacking both Pfa3p and Swf1p had fragmented vacuoles under normal growth conditions [1].
  • Interestingly, Pfa3 is required for the vacuolar localization of not only an SH4 domain that is targeted by myristate/palmitate (as in Vac8) but also one that is targeted by a myristate/basic stretch (as in Src) [2].
  • Moreover, both the DHHC-CRD acyltransferase Pfa3 and Ykt6 are involved in palmitoylation at the vacuole Here, we present and discuss methods to probe for protein palmitoylation at vacuoles [3].


  1. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys, J.E., Schoenfish, M.J., Stutz, M.A., Linder, M.E. J. Cell Biol. (2005) [Pubmed]
  2. The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. Hou, H., Subramanian, K., LaGrassa, T.J., Markgraf, D., Dietrich, L.E., Urban, J., Decker, N., Ungermann, C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Probing protein palmitoylation at the yeast vacuole. Meiringer, C.T., Ungermann, C. Methods (2006) [Pubmed]
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