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Gene Review

BOP3  -  Bop3p

Saccharomyces cerevisiae S288c

Synonyms: Bypass of PAM1 protein 3, N2670, Protein BOP3, YNL042W
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Disease relevance of BOP3

  • These results suggest that multiple proteins are involved in minimizing the toxicity of methylmercury induced by overexpression of Bop3 [1].

High impact information on BOP3

  • Overexpression of Msn2 conferred a much greater sensitivity to methylmercury in yeast, while deletion of the corresponding gene lowered the degree of resistance to methylmercury induced by overexpression of Bop3 [1].
  • However, the increased level of resistance to methylmercury produced by overexpression of Bop3 was smaller in Fhk1-deleted yeast as compared with that of the wild-type strain [1].


  1. Overexpression of Bop3 confers resistance to methylmercury in Saccharomyces cerevisiae through interaction with other proteins such as Fkh1, Rts1, and Msn2. Hwang, G.W., Furuoya, Y., Hiroshima, A., Furuchi, T., Naganuma, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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