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Gene Review

SSK2  -  Ssk2p

Saccharomyces cerevisiae S288c

Synonyms: MAP kinase kinase kinase SSK2, N3276, Suppressor of sensor kinase 2, YNR031C
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High impact information on SSK2

  • Mcs4 acts upstream of Wak1, a homolog of the SSK2 and SSK22 MEK kinases, which transmits the stress signal to the Wis1 MEK [1].
  • The SSK1 C-terminal receiver domain interacts with an N-terminal segment of SSK2 [2].
  • A conserved threonine residue (Thr1460) in the activation loop of SSK2 is important for kinase activity [2].

Other interactions of SSK2

  • Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator [2].


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