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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPG1  -  putative serine/threonine-protein kinase PPG1

Saccharomyces cerevisiae S288c

Synonyms: N3281, PPG, Serine/threonine-protein phosphatase PP2A-like PPG1, YNR032W
 
 
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High impact information on PPG1

  • On the basis of its amino acid sequence, the product of gene PPG would be an acidic protein, structurally more related to type 2A than to type 1 or 2B phosphatases, and is characterized by an extension of about 50 amino acids at the carboxyl terminus [1].
  • A size-selected yeast genomic library was constructed and screened using clone ST4-2 as probe, and one positive clone, named PPG, was isolated [1].
  • In addition, three PP2A-related phosphatases, encoded by PPH3, SIT4 and PPG1, have been identified [2].
  • It has been suggested that in S. macrospora, PPG1/PRE2 and PPG2/PRE1 form two cognate pheromone-receptor pairs [3].

References

  1. The gene PPG encodes a novel yeast protein phosphatase involved in glycogen accumulation. Posas, F., Clotet, J., Muns, M.T., Corominas, J., Casamayor, A., Ariño, J. J. Biol. Chem. (1993) [Pubmed]
  2. Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Zabrocki, P., Van Hoof, C., Goris, J., Thevelein, J.M., Winderickx, J., Wera, S. Mol. Microbiol. (2002) [Pubmed]
  3. Pheromones and pheromone receptors are required for proper sexual development in the homothallic ascomycete Sordaria macrospora. Mayrhofer, S., Weber, J.M., Pöggeler, S. Genetics (2006) [Pubmed]
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