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Gene Review

NOG2  -  putative GTPase NOG2

Saccharomyces cerevisiae S288c

Synonyms: N3484, Nucleolar GTP-binding protein 2, YNR053C
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High impact information on NOG2

  • These results suggest that transient, possibly GTP-dependent association of Nog2p with the pre-ribosomes might trigger late rRNA maturation steps in ribosomal large subunit biogenesis [1].
  • Ist2 is probably involved in osmotolerance, Nog2p is a putative GTPase required for 60S ribosomal subunit maturation, but may also participate in mRNA splicing [2].


  1. Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps. Saveanu, C., Bienvenu, D., Namane, A., Gleizes, P.E., Gas, N., Jacquier, A., Fromont-Racine, M. EMBO J. (2001) [Pubmed]
  2. Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae. Białkowska, A., Kurlandzka, A. Acta Biochim. Pol. (2002) [Pubmed]
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