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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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About

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Gene Review: 

GNL2  -  guanine nucleotide binding protein-like 2...

Homo sapiens

Synonyms: Autoantigen NGP-1, HUMAUANTIG, NGP1, Ngp-1, Nog2, ...
 
 
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Disease relevance of GNL2

  • A cDNA clone encoding an immunoreactive autoantigen (Ngp-1) was isolated by screening lambda gt11 human ductal breast tumor expression libraries with autologous patient serum [1].
 

High impact information on GNL2

  • The arrangement and spacing of the GTP-binding protein motifs indicate that Ngp-1 belongs to a newly described subfamily of GTPases [1].
  • Except for the consensus motifs, neither nucleotide sequence, nor the predicted amino acid sequence of the Ngp-1 cDNA showed the slightest homology to any vertebrate gene product sequence listed in the databases [1].
  • Immunohistochemical analysis of tissue sections with affinity-purified antiserum raised against a recombinant Ngp-1 protein revealed that the antigen was exclusively localized to the nucleolus and nucleolar organizer regions in all cell types analyzed [1].
  • Crystal data: TGP-1, monoclinic, P2(1)/c; a = 25.692(2) A, b = 9.6552(8) A, c = 9.8418(8) A, beta = 96.737(2)(o) , V = 2424.5(3) A(3), and Z = 2; NGP-1, monoclinic, C2/c, a = 20.8363(12) A, b = 11.9546(7) A, c = 16.4577(9) A, beta = 117.285(1)(o) , V = 3643.3(1) A(3), Z = 4 [2].
  • Moreover, assay of mitogenic activity shows that GNL-1 is a strong mitogen, but GNL-2 is lack of the activity [3].
 

Analytical, diagnostic and therapeutic context of GNL2

  • They yield three bands having the respective same molecular masses on SDS-PAGE (GNL-1; alpha-subunit of 34.5 kDa, beta of 37.0, and gamma of 39.0: GNL-2; alpha' of 34.5 kDa, beta' of 37.0, and gamma' of 39.0) [3].

References

  1. Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor. Racevskis, J., Dill, A., Stockert, R., Fineberg, S.A. Cell Growth Differ. (1996) [Pubmed]
  2. New titanium and nickel gallophosphates with layered structures. Lin, C.H., Wang, S.L. Inorganic chemistry. (2005) [Pubmed]
  3. Purification and characterization of novel lectins from Great Northern bean, Phaseolus vulgaris L. Kamemura, K., Furuichi, Y., Umekawa, H., Takahashi, T. Biochim. Biophys. Acta (1993) [Pubmed]
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