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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BMS1  -  GTPase BMS1

Saccharomyces cerevisiae S288c

Synonyms: Ribosome biogenesis protein BMS1, YPL217C
 
 
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High impact information on BMS1

  • Together, these data suggest that Bms1 functions as a GTP-regulated switch to deliver Rcl1 to preribosomes, providing molecular insight into preribosome assembly [1].
  • Tsr1p shares two extended regions of similarity with Bms1p, but the two proteins function at different steps in 40S ribosome maturation [2].
  • Finally, Bms1p is a GTP-binding protein, the first found to function in ribosome assembly or rRNA processing [2].
 

Biological context of BMS1

  • Here, we show thermodynamic coupling in the binding of Bms1 to GTP, Rcl1, and U3 small nucleolar RNA (snoRNA), an essential RNA that base pairs to pre-rRNA [1].
  • Bms1p, a G-domain-containing protein, associates with Rcl1p and is required for 18S rRNA biogenesis in yeast [3].
 

Regulatory relationships of BMS1

  • Rcl1 binding to preribosomes is severely limited in yeast cells expressing a Bms1 mutant defective for Rcl1 binding [1].
 

Other interactions of BMS1

  • Here we report the characterization of Bms1p, a protein that associates with Rcl1p in multiple structures, including a specific complex sedimenting at around 10S [3].

References

  1. An essential GTPase promotes assembly of preribosomal RNA processing complexes. Karbstein, K., Jonas, S., Doudna, J.A. Mol. Cell (2005) [Pubmed]
  2. Bms1p, a novel GTP-binding protein, and the related Tsr1p are required for distinct steps of 40S ribosome biogenesis in yeast. Gelperin, D., Horton, L., Beckman, J., Hensold, J., Lemmon, S.K. RNA (2001) [Pubmed]
  3. Bms1p, a G-domain-containing protein, associates with Rcl1p and is required for 18S rRNA biogenesis in yeast. Wegierski, T., Billy, E., Nasr, F., Filipowicz, W. RNA (2001) [Pubmed]
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