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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SMX3  -  Smx3p

Saccharomyces cerevisiae S288c

Synonyms: P9705.4, Sm protein F, Sm-F, SmF, Small nuclear ribonucleoprotein F, ...
 
 
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High impact information on SMX3

  • Surprisingly, we observed that other evolutionarily conserved positions are tolerant to mutations, with substitutions affecting binding to SmF and SmG only mildly and conferring a wild-type growth phenotype [1].
  • To map the protein-protein interaction surface of Sm proteins, we generated a library of SmE mutants and investigated their ability to interact with SmF and/or SmG proteins in the two-hybrid system [1].
  • Formation of homo-oligomers by the spliceosomal small nuclear ribonucleoprotein components SmE and SmF preclude hetero-interactions vital to formation of functional small nuclear RNP complexes in vivo [2].
  • Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF [2].

References

  1. Interactions within the yeast Sm core complex: from proteins to amino acids. Camasses, A., Bragado-Nilsson, E., Martin, R., Séraphin, B., Bordonné, R. Mol. Cell. Biol. (1998) [Pubmed]
  2. Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF. Collins, B.M., Cubeddu, L., Naidoo, N., Harrop, S.J., Kornfeld, G.D., Dawes, I.W., Curmi, P.M., Mabbutt, B.C. J. Biol. Chem. (2003) [Pubmed]
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