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Gene Review

RNP1  -  Rnp1p

Saccharomyces cerevisiae S288c

Synonyms: Ribonucleoprotein 1, YLL046C
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Disease relevance of RNP1


High impact information on RNP1


Biological context of RNP1

  • The RNP1 gene maps to the left arm of chromosome XIV centromere distal to SUF10 [11].
  • Two null mutants of RNP1 that were created, a frameshift disruption and a complete deletion of the gene, were viable, demonstrating that the gene is not essential for cell growth [12].
  • Internal sequence information of purified p60 reveals identity with the open reading frames of genes PUB1 and RNP1 which encode polyuridylate binding protein(s) [13].
  • However genomic Southern blot analysis indicated that several other loci in the S. cerevisiae genome appear to contain sequences similar to those in the RNP1 gene [11].
  • Haploid yeast containing a null allele of RNP1 are viable, indicating that RNP1 is dispensible for mitotic growth [11].

Anatomical context of RNP1


Associations of RNP1 with chemical compounds


Physical interactions of RNP1

  • In this work we show that TcUBP-1 is part of an approximately 450-kDa ribonucleoprotein complex with a poly(A)-binding protein and a novel 18-kDa RNA-binding protein, named TcUBP-2 [23].
  • Bud-specific enrichment depends on Myo4p's association with its cargo, a ribonucleoprotein complex containing the RNA-binding protein She2p [24].
  • Scp160p is an RNA-binding protein containing 14 tandemly repeated heterogenous nuclear ribonucleoprotein K-homology domains, which are implicated in RNA binding [25].
  • This ribonucleoprotein complex is transported to the distal tip of the bud along polarized actin cables [26].
  • A novel ribonucleoprotein complex enriched in nucleolar proteins was purified from yeast extracts and constituents were identified by mass spectrometry [27].

Other interactions of RNP1


Analytical, diagnostic and therapeutic context of RNP1


  1. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. O'Neill, R.E., Talon, J., Palese, P. EMBO J. (1998) [Pubmed]
  2. Molecular cloning of Xenopus fibrillarin, a conserved U3 small nuclear ribonucleoprotein recognized by antisera from humans with autoimmune disease. Lapeyre, B., Mariottini, P., Mathieu, C., Ferrer, P., Amaldi, F., Amalric, F., Caizergues-Ferrer, M. Mol. Cell. Biol. (1990) [Pubmed]
  3. The bipartite 3'-cis-acting signal for replication is required for formation of a ribonucleoprotein complex in vivo between the viral genome and its RNA polymerase in yeast 23 S RNA virus. Fujimura, T., Esteban, R. J. Biol. Chem. (2004) [Pubmed]
  4. The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2. Wadd, S., Bryant, H., Filhol, O., Scott, J.E., Hsieh, T.Y., Everett, R.D., Clements, J.B. J. Biol. Chem. (1999) [Pubmed]
  5. Functional interaction map of lyssavirus phosphoprotein: identification of the minimal transcription domains. Jacob, Y., Real, E., Tordo, N. J. Virol. (2001) [Pubmed]
  6. She2p is a novel RNA binding protein with a basic helical hairpin motif. Niessing, D., Hüttelmaier, S., Zenklusen, D., Singer, R.H., Burley, S.K. Cell (2004) [Pubmed]
  7. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Weeks, K.M., Cech, T.R. Cell (1995) [Pubmed]
  8. Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria. Kennell, J.C., Moran, J.V., Perlman, P.S., Butow, R.A., Lambowitz, A.M. Cell (1993) [Pubmed]
  9. Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions. Lossky, M., Anderson, G.J., Jackson, S.P., Beggs, J. Cell (1987) [Pubmed]
  10. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Dragon, F., Gallagher, J.E., Compagnone-Post, P.A., Mitchell, B.M., Porwancher, K.A., Wehner, K.A., Wormsley, S., Settlage, R.E., Shabanowitz, J., Osheim, Y., Beyer, A.L., Hunt, D.F., Baserga, S.J. Nature (2002) [Pubmed]
  11. A protein containing conserved RNA-recognition motifs is associated with ribosomal subunits in Saccharomyces cerevisiae. Ripmaster, T.L., Woolford, J.L. Nucleic Acids Res. (1993) [Pubmed]
  12. RNP1, a new ribonucleoprotein gene of the yeast Saccharomyces cerevisiae. Cusick, M.E. Nucleic Acids Res. (1994) [Pubmed]
  13. The yeast protein encoded by PUB1 binds T-rich single stranded DNA. Cockell, M., Frutiger, S., Hughes, G.J., Gasser, S.M. Nucleic Acids Res. (1994) [Pubmed]
  14. Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs. Tollervey, D., Mattaj, I.W. EMBO J. (1987) [Pubmed]
  15. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. Brown, J.D., Hann, B.C., Medzihradszky, K.F., Niwa, M., Burlingame, A.L., Walter, P. EMBO J. (1994) [Pubmed]
  16. The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export. Green, D.M., Johnson, C.P., Hagan, H., Corbett, A.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. Kosturko, L.D., Maggipinto, M.J., D'Sa, C., Carson, J.H., Barbarese, E. Mol. Biol. Cell (2005) [Pubmed]
  18. Nuclear export of hnRNP Hrp1p and nuclear export of hnRNP Npl3p are linked and influenced by the methylation state of Npl3p. Xu, C., Henry, M.F. Mol. Cell. Biol. (2004) [Pubmed]
  19. Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1. Steinmetz, E.J., Brow, D.A. Mol. Cell. Biol. (1996) [Pubmed]
  20. The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing. Huang, H.R., Chao, M.Y., Armstrong, B., Wang, Y., Lambowitz, A.M., Perlman, P.S. Mol. Cell. Biol. (2003) [Pubmed]
  21. Studies of RNA-protein interactions in the yeast 5 S ribonucleoprotein particles by fluorescence and tritium exchange. Implications for ribosomal assembly. Yeh, L.C., Horowitz, P.M., Lee, J.C. J. Biol. Chem. (1988) [Pubmed]
  22. Analysis of the binding of the N-terminal conserved domain of yeast Cbf5p to a box H/ACA snoRNA. Normand, C., Capeyrou, R., Quevillon-Cheruel, S., Mougin, A., Henry, Y., Caizergues-Ferrer, M. RNA (2006) [Pubmed]
  23. TcUBP-1, an mRNA destabilizing factor from trypanosomes, homodimerizes and interacts with novel AU-rich element- and Poly(A)-binding proteins forming a ribonucleoprotein complex. D'Orso, I., Frasch, A.C. J. Biol. Chem. (2002) [Pubmed]
  24. Ribonucleoprotein-dependent localization of the yeast class V myosin Myo4p. Kruse, C., Jaedicke, A., Beaudouin, J., Bohl, F., Ferring, D., Guttler, T., Ellenberg, J., Jansen, R.P. J. Cell Biol. (2002) [Pubmed]
  25. Scp160p, an RNA-binding, polysome-associated protein, localizes to the endoplasmic reticulum of Saccharomyces cerevisiae in a microtubule-dependent manner. Frey, S., Pool, M., Seedorf, M. J. Biol. Chem. (2001) [Pubmed]
  26. RNA localization in yeast: moving towards a mechanism. Gonsalvez, G.B., Urbinati, C.R., Long, R.M. Biol. Cell (2005) [Pubmed]
  27. Association of yeast RNA polymerase I with a nucleolar substructure active in rRNA synthesis and processing. Fath, S., Milkereit, P., Podtelejnikov, A.V., Bischler, N., Schultz, P., Bier, M., Mann, M., Tschochner, H. J. Cell Biol. (2000) [Pubmed]
  28. The yeast NOP4 gene product is an essential nucleolar protein required for pre-rRNA processing and accumulation of 60S ribosomal subunits. Sun, C., Woolford, J.L. EMBO J. (1994) [Pubmed]
  29. Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. Wilson, S.M., Datar, K.V., Paddy, M.R., Swedlow, J.R., Swanson, M.S. J. Cell Biol. (1994) [Pubmed]
  30. Yeast Pab1 interacts with Rna15 and participates in the control of the poly(A) tail length in vitro. Amrani, N., Minet, M., Le Gouar, M., Lacroute, F., Wyers, F. Mol. Cell. Biol. (1997) [Pubmed]
  31. Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast. Nielsen, K.H., Valásek, L., Sykes, C., Jivotovskaya, A., Hinnebusch, A.G. Mol. Cell. Biol. (2006) [Pubmed]
  32. 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. Shen, E.C., Stage-Zimmermann, T., Chui, P., Silver, P.A. J. Biol. Chem. (2000) [Pubmed]
  33. Cytoplasmic transport of ribosomal subunits microinjected into the Xenopus laevis oocyte nucleus: a generalized, facilitated process. Bataillé, N., Helser, T., Fried, H.M. J. Cell Biol. (1990) [Pubmed]
  34. Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP. Lücke, S., Klöckner, T., Palfi, Z., Boshart, M., Bindereif, A. EMBO J. (1997) [Pubmed]
  35. Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family. Nakagawa, T.Y., Swanson, M.S., Wold, B.J., Dreyfuss, G. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  36. PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Bjørn, S.P., Soltyk, A., Beggs, J.D., Friesen, J.D. Mol. Cell. Biol. (1989) [Pubmed]
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