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Gene Review

CTF8  -  Ctf8p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome transmission fidelity protein 8, YHR191C
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High impact information on CTF8

  • We performed synthetic genetic array (SGA) analysis with a ctf8 deletion strain as a primary screen to identify other nonessential genes required for efficient sister chromatid cohesion [1].
  • Our finding that cells deleted for CTF8, CTF4 or CHL1 undergo massive meiosis II non-disjunction suggests that the second meiotic division is particularly sensitive to cohesion defects [2].


  1. Identification of protein complexes required for efficient sister chromatid cohesion. Mayer, M.L., Pot, I., Chang, M., Xu, H., Aneliunas, V., Kwok, T., Newitt, R., Aebersold, R., Boone, C., Brown, G.W., Hieter, P. Mol. Biol. Cell (2004) [Pubmed]
  2. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. Petronczki, M., Chwalla, B., Siomos, M.F., Yokobayashi, S., Helmhart, W., Deutschbauer, A.M., Davis, R.W., Watanabe, Y., Nasmyth, K. J. Cell. Sci. (2004) [Pubmed]
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