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Gene Review

PMP2  -  Pmp2p

Saccharomyces cerevisiae S288c

Synonyms: Plasma membrane ATPase proteolipid 2, YEL017BC, YEL017C-A
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High impact information on PMP2

  • The two proteolipids differ at residue 21, which is an alanine in PMP1 and a serine in PMP2 [1].
  • PMP2 encodes a 43-amino acid polypeptide that can be extracted from the membrane with chloroform/methanol [1].
  • Multimeric presentation of the Arg-based signal from Kir6.2 on Pmp2p results in forward transport, which requires 14-3-3 proteins encoded in yeast by BMH1 and BMH2 in two isoforms [2].
  • The Pmp2p isoproteolipid, a type I yeast membrane protein, reports faithfully on the activity of sorting signals when fused to a tail containing either an Arg-based motif or a -KKXX signal [2].


  1. Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. Navarre, C., Catty, P., Leterme, S., Dietrich, F., Goffeau, A. J. Biol. Chem. (1994) [Pubmed]
  2. A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Michelsen, K., Mrowiec, T., Duderstadt, K.E., Frey, S., Minor, D.L., Mayer, M.P., Schwappach, B. Traffic (2006) [Pubmed]
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